Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-3-5
|
| pubmed:abstractText |
Status asthmaticus (SA) is an acute respiratory failure combining an acute bronchospastic reaction with a severe airway inflammation. We previously reported an important influx of neutrophils and an increased secretion of interleukin-8 (IL-8) in patients with SA. The aim of this prospective study was to evaluate in bronchial lavage (BL) of patients with SA (n = 9) under mechanical ventilation (MV) the concentrations of cytokines and related mediators which have the ability to modulate inflammation, either proinflammatory (interleukin-1beta [IL-1beta], IL-6, tumor necrosis factor-alpha [TNF-alpha]), or anti-inflammatory mediators (IL-10, transforming growth factor-beta1 [TGF-beta1]), interleukin-1 receptor antagonist [IL-1Ra], soluble TNF receptor I and II [sTNFRI and II]). To determine the relative importance of both pro- and anti-inflammatory mediators, the net inflammatory activity was analyzed by the capacity of BL fluids (BLF) to increase intercellular adhesion molecule-1 (ICAM-1) expression in the human lung A549 epithelial cell line. These data were compared with those obtained from patients who required MV without respiratory disease (V, n = 4), controlled asthma (A, n = 11), and nonsmoking healthy volunteers (C, n = 8). Levels of IL-1, IL-6, TNF-alpha, and of the active form of TGF-beta1 were significantly higher in SA compared with the other groups. The concentrations of IL-1Ra, IL-10, the latent form of TGF-beta1, and of the sTNFRI and II were not significantly different between SA and V, albeit higher in SA than in A and C. The ratio between IL-1Ra and IL-1beta was significantly higher in patients with SA compared with the other groups, whereas there was no difference for the ratio between both types of sTNFR and TNF-alpha. Despite a marked increase of anti-inflammatory mediators in BL from patients with SA, the net inflammatory activity was found to be proinflammatory and mainly due to the presence of bioactive IL-1beta (79% inhibition of ICAM-1 expression with anti-IL-1beta antibodies) and to a lesser extent TNF-alpha (32% inhibition with anti-TNF-alpha antibodies).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/IL1RN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
159
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
487-94
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9927362-Adult,
pubmed-meshheading:9927362-Antigens, CD,
pubmed-meshheading:9927362-Biological Markers,
pubmed-meshheading:9927362-Bronchoalveolar Lavage,
pubmed-meshheading:9927362-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:9927362-Bronchoscopy,
pubmed-meshheading:9927362-Cytokines,
pubmed-meshheading:9927362-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9927362-Female,
pubmed-meshheading:9927362-Humans,
pubmed-meshheading:9927362-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:9927362-Interleukin-1,
pubmed-meshheading:9927362-Interleukin-10,
pubmed-meshheading:9927362-Interleukin-6,
pubmed-meshheading:9927362-Male,
pubmed-meshheading:9927362-Middle Aged,
pubmed-meshheading:9927362-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:9927362-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:9927362-Respiration, Artificial,
pubmed-meshheading:9927362-Sialoglycoproteins,
pubmed-meshheading:9927362-Status Asthmaticus,
pubmed-meshheading:9927362-Transforming Growth Factor beta,
pubmed-meshheading:9927362-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus.
|
| pubmed:affiliation |
Unité INSERM U 416, Institut Pasteur de Lille, France.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|