Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-2-10
|
| pubmed:abstractText |
The MET protooncogene encodes a transmembrane tyrosine kinase identified as the receptor of a polypeptide known as hepatocyte growth factor/scatter factor. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the tyrosine kinase domain of the MET gene (exon 15-19) in 75 primary liver cancers. Three missense mutations were detected exclusively in 10 childhood hepatocellular carcinomas (HCCs), while no mutations were detected in 16 adult HCCs, 21 cholangiocarcinomas, or 28 hepatoblastomas. The extremely short incubation period from hepatitis B virus infection to the genesis of childhood HCC as compared with the adult HCC suggests that there may be an additional mechanism that accelerates the carcinogenesis of childhood HCC. Our results indicate that mutations of the tyrosine kinase domain of the MET gene may be involved in the acceleration of the carcinogenesis in childhood HCC.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0008-5472
|
| pubmed:author |
pubmed-author:DIKH JHJ,
pubmed-author:DoneS SSS,
pubmed-author:HongY KYK,
pubmed-author:JangJ JJJ,
pubmed-author:KimB JBJ,
pubmed-author:KimS YSY,
pubmed-author:LeeJ YJY,
pubmed-author:LeeK SKS,
pubmed-author:LeeS HSH,
pubmed-author:NaE YEY,
pubmed-author:OuJ CJC,
pubmed-author:PackSS,
pubmed-author:ParkW SWS,
pubmed-author:SchmidtLL,
pubmed-author:ShinM SMS,
pubmed-author:YooN JNJ,
pubmed-author:ZbarBB,
pubmed-author:ZhuangZZ
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
59
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
307-10
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:9927037-Adolescent,
pubmed-meshheading:9927037-Adult,
pubmed-meshheading:9927037-Aged,
pubmed-meshheading:9927037-Carcinoma, Hepatocellular,
pubmed-meshheading:9927037-Child,
pubmed-meshheading:9927037-Female,
pubmed-meshheading:9927037-Hepatitis B,
pubmed-meshheading:9927037-Humans,
pubmed-meshheading:9927037-Liver Neoplasms,
pubmed-meshheading:9927037-Male,
pubmed-meshheading:9927037-Middle Aged,
pubmed-meshheading:9927037-Mutation,
pubmed-meshheading:9927037-Proto-Oncogene Proteins c-met
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.
|
| pubmed:affiliation |
Department of Pathology and Cancer Research Institute, Catholic University Medical College, Seoul, Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|