| pubmed-article:9925898 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9925898 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9925898 | lifeskim:mentions | umls-concept:C0014653 | lld:lifeskim |
| pubmed-article:9925898 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:9925898 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:9925898 | lifeskim:mentions | umls-concept:C1514989 | lld:lifeskim |
| pubmed-article:9925898 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:9925898 | pubmed:dateCreated | 1999-5-7 | lld:pubmed |
| pubmed-article:9925898 | pubmed:abstractText | 1. The present study investigates to what extent and by which time course prolonged strenuous exercise influences the plasma concentration of pro-inflammatory and inflammation responsive cytokines as well as cytokine inhibitors and anti-inflammatory cytokines. 2. Ten male subjects (median age 27.5 years, range 24-37) completed the Copenhagen Marathon 1997 (median running time 3 : 26 (h : min), range 2 : 40-4 : 20). Blood samples were obtained before, immediately after and then every 30 min in a 4 h post-exercise recovery period. 3. The plasma concentrations of tumour necrosis factor (TNF)alpha, interleukin (IL)-1beta, IL-6, IL-1ra, sTNF-r1, sTNF-r2 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). The highest concentration of IL-6 was found immediately after the race, whereas IL-1ra peaked 1 h post exercise (128-fold and 39-fold increase, respectively, as compared with the pre-exercise values). The plasma level of IL-1beta, TNFalpha, sTNF-r1 and sTNF-r2 peaked in the first hour after the exercise (2. 1-, 2.3-, 2.7- and 1.6-fold, respectively). The plasma level of IL-10 showed a 27-fold increase immediately post exercise. 4. In conclusion, strenuous exercise induces an increase in the pro-inflammatory cytokines TNFalpha and IL-1beta and a dramatic increase in the inflammation responsive cytokine IL-6. This is balanced by the release of cytokine inhibitors (IL-1ra, sTNF-r1 and sTNF-r2) and the anti-inflammatory cytokine IL-10. The study suggests that cytokine inhibitors and anti-inflammatory cytokines restrict the magnitude and duration of the inflammatory response to exercise. | lld:pubmed |
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| pubmed-article:9925898 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9925898 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9925898 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9925898 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9925898 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9925898 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:9925898 | pubmed:author | pubmed-author:OstrowskiKK | lld:pubmed |
| pubmed-article:9925898 | pubmed:author | pubmed-author:AspSS | lld:pubmed |
| pubmed-article:9925898 | pubmed:author | pubmed-author:PedersenB KBK | lld:pubmed |
| pubmed-article:9925898 | pubmed:author | pubmed-author:RohdeTT | lld:pubmed |
| pubmed-article:9925898 | pubmed:author | pubmed-author:SchjerlingPP | lld:pubmed |
| pubmed-article:9925898 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9925898 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9925898 | pubmed:volume | 515 ( Pt 1) | lld:pubmed |
| pubmed-article:9925898 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9925898 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9925898 | pubmed:pagination | 287-91 | lld:pubmed |
| pubmed-article:9925898 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9925898 | pubmed:meshHeading | pubmed-meshheading:9925898-... | lld:pubmed |
| pubmed-article:9925898 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9925898 | pubmed:articleTitle | Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. | lld:pubmed |
| pubmed-article:9925898 | pubmed:affiliation | The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen and The Department of Infectious Diseases M, Rigshospitalet, Copenhagen, Denmark.ko@rh.dk | lld:pubmed |
| pubmed-article:9925898 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9925898 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9925898 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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