Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-5-7
pubmed:abstractText
1. The present study investigates to what extent and by which time course prolonged strenuous exercise influences the plasma concentration of pro-inflammatory and inflammation responsive cytokines as well as cytokine inhibitors and anti-inflammatory cytokines. 2. Ten male subjects (median age 27.5 years, range 24-37) completed the Copenhagen Marathon 1997 (median running time 3 : 26 (h : min), range 2 : 40-4 : 20). Blood samples were obtained before, immediately after and then every 30 min in a 4 h post-exercise recovery period. 3. The plasma concentrations of tumour necrosis factor (TNF)alpha, interleukin (IL)-1beta, IL-6, IL-1ra, sTNF-r1, sTNF-r2 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). The highest concentration of IL-6 was found immediately after the race, whereas IL-1ra peaked 1 h post exercise (128-fold and 39-fold increase, respectively, as compared with the pre-exercise values). The plasma level of IL-1beta, TNFalpha, sTNF-r1 and sTNF-r2 peaked in the first hour after the exercise (2. 1-, 2.3-, 2.7- and 1.6-fold, respectively). The plasma level of IL-10 showed a 27-fold increase immediately post exercise. 4. In conclusion, strenuous exercise induces an increase in the pro-inflammatory cytokines TNFalpha and IL-1beta and a dramatic increase in the inflammation responsive cytokine IL-6. This is balanced by the release of cytokine inhibitors (IL-1ra, sTNF-r1 and sTNF-r2) and the anti-inflammatory cytokine IL-10. The study suggests that cytokine inhibitors and anti-inflammatory cytokines restrict the magnitude and duration of the inflammatory response to exercise.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-1506003, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-1611721, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-1910016, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-2141475, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-2628363, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-3491061, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-3491062, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-4850854, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-6836306, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-7932079, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-7961280, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-8063468, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-8163946, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-8186324, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-8274730, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-8594005, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-9007457, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-9023782, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-9130176, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-9134917, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-9252483, http://linkedlifedata.com/resource/pubmed/commentcorrection/9925898-9518745
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
515 ( Pt 1)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-91
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans.
pubmed:affiliation
The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen and The Department of Infectious Diseases M, Rigshospitalet, Copenhagen, Denmark.ko@rh.dk
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't