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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
12
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|
pubmed:dateCreated |
1999-3-31
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|
pubmed:abstractText |
In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Dec
|
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pubmed:issn |
0968-0896
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
6
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2449-58
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9925301-Antineoplastic Agents,
pubmed-meshheading:9925301-Cell Survival,
pubmed-meshheading:9925301-Computer Graphics,
pubmed-meshheading:9925301-Humans,
pubmed-meshheading:9925301-Indicators and Reagents,
pubmed-meshheading:9925301-Isoquinolines,
pubmed-meshheading:9925301-Melanoma,
pubmed-meshheading:9925301-Models, Molecular,
pubmed-meshheading:9925301-Molecular Structure,
pubmed-meshheading:9925301-Regression Analysis,
pubmed-meshheading:9925301-Reproducibility of Results,
pubmed-meshheading:9925301-Static Electricity,
pubmed-meshheading:9925301-Structure-Activity Relationship,
pubmed-meshheading:9925301-Tumor Cells, Cultured
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|
pubmed:year |
1998
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pubmed:articleTitle |
Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives.
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pubmed:affiliation |
College of Pharmacy, Chonnam National University, Kwangju, Korea. wjcho@chonnam.chonnam.ac.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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