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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-2-4
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pubmed:abstractText |
Prior single-photon emission tomography studies showed losses of muscarinic acetylcholine receptor (MAChR) binding in patients with refractory mesial temporal lobe epilepsy. Experimental animal studies demonstrated transient losses of MAChR due to electrically induced seizures originating in the amygdala. However, the relations between cholinergic synaptic markers, seizures, and underlying neuropathology in human temporal lobe epilepsy are unknown. We tested the hypotheses that human brain MAChR changes are attributable to hippocampal sclerosis (HS), and that HS resembles axon-sparing lesions in experimental animal models.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0013-9580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38-46
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9924900-Adult,
pubmed-meshheading:9924900-Age Factors,
pubmed-meshheading:9924900-Aged,
pubmed-meshheading:9924900-Biological Markers,
pubmed-meshheading:9924900-Child,
pubmed-meshheading:9924900-Cholinergic Fibers,
pubmed-meshheading:9924900-Epilepsy, Temporal Lobe,
pubmed-meshheading:9924900-Female,
pubmed-meshheading:9924900-Hippocampus,
pubmed-meshheading:9924900-Humans,
pubmed-meshheading:9924900-Male,
pubmed-meshheading:9924900-Presynaptic Terminals,
pubmed-meshheading:9924900-Receptors, Cholinergic,
pubmed-meshheading:9924900-Receptors, Muscarinic,
pubmed-meshheading:9924900-Regression Analysis,
pubmed-meshheading:9924900-Sclerosis,
pubmed-meshheading:9924900-Scopolamine Hydrobromide,
pubmed-meshheading:9924900-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:9924900-Tritium
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pubmed:year |
1999
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pubmed:articleTitle |
Muscarinic receptor loss and preservation of presynaptic cholinergic terminals in hippocampal sclerosis.
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pubmed:affiliation |
Department of Neurology, The University of Michigan School of Medicine, Ann Arbor, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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