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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1999-2-9
|
| pubmed:abstractText |
An epidemiological method, field-tested in Hunan, China, to identify residents potentially susceptible or insusceptible to endemic schistosomiasis japonica is described, as a prelude to selection of subjects for immunogenetic studies. After an initial cross-sectional survey on two islands (Qingshan and Niangashan--population 2990) in 1995-1996, an informative cohort (N = 249) was selected for treatment and 9-month follow-up to measure exposure and re-infection. Both the population prevalence (15.8%) and the geometric mean intensity of infection (26.2 eggs/g faces) indicated that the islands were moderately endemic for schistosomiasis. Exposure measurements revealed a strong, positive, linear association (r = 0.70) between daily activity diaries and direct water-contact observation. Individuals identified as stool-positive for schistosomiasis had significantly more water contact than those who were egg-negative (P = 0.03). Almost all (93%) of the cohort had ultrasonographic evidence of periportal fibrosis before treatment but in only 1.2% was this fibrosis scored > 1 in terms of the stages identified by the World Health Organization. At the follow-up it was possible to classify the 249 subjects into three, distinct, exposure-infection epidemiological groups. The first group (N = 20) was susceptible to re-infection and constituted 8% of the cohort. The second group (N = 61) was apparently insusceptible to re-infection despite the continuing high levels of exposure and included 24% of the cohort. The other 68% of the cohort (N = 168) remained uninfected but were at most only moderately exposed, or had a status indeterminate due to non-compliance. This epidemiological identification of susceptibles and insusceptibles for schistosomiasis japonica' links field and ongoing laboratory studies aimed at characterising the genetic and immunological factors associated with resistance to re-infection and/or disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0003-4983
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
92
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
765-74
|
| pubmed:dateRevised |
2009-5-18
|
| pubmed:meshHeading |
pubmed-meshheading:9924534-Adolescent,
pubmed-meshheading:9924534-Adult,
pubmed-meshheading:9924534-Aged,
pubmed-meshheading:9924534-Aged, 80 and over,
pubmed-meshheading:9924534-Analysis of Variance,
pubmed-meshheading:9924534-Animals,
pubmed-meshheading:9924534-Child,
pubmed-meshheading:9924534-Child, Preschool,
pubmed-meshheading:9924534-China,
pubmed-meshheading:9924534-Cross-Sectional Studies,
pubmed-meshheading:9924534-Disease Susceptibility,
pubmed-meshheading:9924534-Female,
pubmed-meshheading:9924534-Humans,
pubmed-meshheading:9924534-Male,
pubmed-meshheading:9924534-Middle Aged,
pubmed-meshheading:9924534-Parasite Egg Count,
pubmed-meshheading:9924534-Praziquantel,
pubmed-meshheading:9924534-Prevalence,
pubmed-meshheading:9924534-Rural Health,
pubmed-meshheading:9924534-Schistosoma japonicum,
pubmed-meshheading:9924534-Schistosomiasis japonica,
pubmed-meshheading:9924534-Schistosomicides,
pubmed-meshheading:9924534-Sex Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Epidemiological identification of Chinese individuals putatively susceptible or insusceptible to Schistosoma japonicum: a prelude to immunogenetic study of human resistance to Asian schistosomiasis.
|
| pubmed:affiliation |
Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|