rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5402
|
pubmed:dateCreated |
1999-2-11
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pubmed:abstractText |
All four members of the family of pentopyranosyl-(2'-->4') oligonucleotide systems that contain beta-ribo-, beta-xylo-, alpha-lyxo-, or alpha-arabinopyranosyl units as repeating sugar building blocks are found to be much stronger Watson-Crick base-pairing systems than RNA. The alpha-arabinopyranosyl system is the strongest of all and in fact belongs to the strongest oligonucleotide base-pairing systems known. Whatever the chemical determinants by which nature selected RNA as a genetic system, maximization of base-pairing strengths within the domain of pentose-derived oligonucleotide systems was not the critical selection criterion.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0036-8075
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
29
|
pubmed:volume |
283
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
699-703
|
pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:9924032-Arabinose,
pubmed-meshheading:9924032-Base Pairing,
pubmed-meshheading:9924032-Circular Dichroism,
pubmed-meshheading:9924032-Evolution, Molecular,
pubmed-meshheading:9924032-Nucleic Acid Conformation,
pubmed-meshheading:9924032-Nucleic Acid Denaturation,
pubmed-meshheading:9924032-Oligonucleotides,
pubmed-meshheading:9924032-Oligoribonucleotides,
pubmed-meshheading:9924032-Pentoses,
pubmed-meshheading:9924032-RNA,
pubmed-meshheading:9924032-Ribose,
pubmed-meshheading:9924032-Temperature,
pubmed-meshheading:9924032-Thermodynamics,
pubmed-meshheading:9924032-Xylose
|
pubmed:year |
1999
|
pubmed:articleTitle |
Chemical etiology of nucleic acid structure: comparing pentopyranosyl-(2'-->4') oligonucleotides with RNA.
|
pubmed:affiliation |
The Skaggs Institute for Chemical Biology at The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|