| pubmed-article:9924025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9924025 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:9924025 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9924025 | lifeskim:mentions | umls-concept:C0700114 | lld:lifeskim |
| pubmed-article:9924025 | lifeskim:mentions | umls-concept:C1442498 | lld:lifeskim |
| pubmed-article:9924025 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9924025 | lifeskim:mentions | umls-concept:C0162905 | lld:lifeskim |
| pubmed-article:9924025 | pubmed:issue | 5402 | lld:pubmed |
| pubmed-article:9924025 | pubmed:dateCreated | 1999-2-11 | lld:pubmed |
| pubmed-article:9924025 | pubmed:abstractText | The protein encoded by the c-MYC proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the intracellular iron pool. Down-regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC. These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC. | lld:pubmed |
| pubmed-article:9924025 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9924025 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9924025 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9924025 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9924025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9924025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9924025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9924025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9924025 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9924025 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:9924025 | pubmed:author | pubmed-author:PolackAA | lld:pubmed |
| pubmed-article:9924025 | pubmed:author | pubmed-author:Dalla-FaveraR... | lld:pubmed |
| pubmed-article:9924025 | pubmed:author | pubmed-author:WuK JKJ | lld:pubmed |
| pubmed-article:9924025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9924025 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:9924025 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:9924025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9924025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9924025 | pubmed:pagination | 676-9 | lld:pubmed |
| pubmed-article:9924025 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9924025 | pubmed:meshHeading | pubmed-meshheading:9924025-... | lld:pubmed |
| pubmed-article:9924025 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9924025 | pubmed:articleTitle | Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. | lld:pubmed |
| pubmed-article:9924025 | pubmed:affiliation | Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA. an. | lld:pubmed |
| pubmed-article:9924025 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9924025 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9924025 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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