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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5402
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pubmed:dateCreated |
1999-2-11
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pubmed:abstractText |
The protein encoded by the c-MYC proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the intracellular iron pool. Down-regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC. These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Ferritins,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Iron Regulatory Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Iron-Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Iron-Sulfur Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transferrin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
283
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
676-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9924025-Animals,
pubmed-meshheading:9924025-Cell Division,
pubmed-meshheading:9924025-Cell Line,
pubmed-meshheading:9924025-Cell Line, Transformed,
pubmed-meshheading:9924025-Cell Transformation, Neoplastic,
pubmed-meshheading:9924025-DNA,
pubmed-meshheading:9924025-Down-Regulation,
pubmed-meshheading:9924025-Ferritins,
pubmed-meshheading:9924025-Gene Expression Regulation,
pubmed-meshheading:9924025-Genes, myc,
pubmed-meshheading:9924025-Homeostasis,
pubmed-meshheading:9924025-Iron,
pubmed-meshheading:9924025-Iron Regulatory Protein 2,
pubmed-meshheading:9924025-Iron-Regulatory Proteins,
pubmed-meshheading:9924025-Iron-Sulfur Proteins,
pubmed-meshheading:9924025-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:9924025-RNA,
pubmed-meshheading:9924025-RNA-Binding Proteins,
pubmed-meshheading:9924025-Receptors, Transferrin,
pubmed-meshheading:9924025-Transcription, Genetic,
pubmed-meshheading:9924025-Transfection
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pubmed:year |
1999
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pubmed:articleTitle |
Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC.
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pubmed:affiliation |
Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA. an.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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