rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1999-2-11
|
pubmed:abstractText |
We purified an antibacterial substance from larvae of the saw fly, Acantholyda parki S., and identified its molecular structure as p-hydroxycinnamaldehyde. We then synthesized it by reduction of p-hydroxycinnamic acid. The antibacterial activity of the synthetic p-hydroxycinnamaldehyde was equal to that of the authentic substance. This molecule was found to have a broad antibacterial spectrum against not only Gram-negative, but also Gram-positive bacteria. Furthermore, it showed antifungal activity against Candida albicans. We suggest that this substance may play a role in the defense system of this insect. This is the first report of p-hydroxycinnamaldehyde of animal origin.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0014-5793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
8
|
pubmed:volume |
442
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
53-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9923603-Animals,
pubmed-meshheading:9923603-Anti-Bacterial Agents,
pubmed-meshheading:9923603-Anti-Infective Agents,
pubmed-meshheading:9923603-Antifungal Agents,
pubmed-meshheading:9923603-Candida albicans,
pubmed-meshheading:9923603-Chromatography, High Pressure Liquid,
pubmed-meshheading:9923603-Cinnamates,
pubmed-meshheading:9923603-Gram-Negative Bacteria,
pubmed-meshheading:9923603-Gram-Positive Bacteria,
pubmed-meshheading:9923603-Hymenoptera,
pubmed-meshheading:9923603-Larva,
pubmed-meshheading:9923603-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9923603-Spectrophotometry, Ultraviolet
|
pubmed:year |
1999
|
pubmed:articleTitle |
Isolation of p-hydroxycinnamaldehyde as an antibacterial substance from the saw fly, Acantholyda parki S.
|
pubmed:affiliation |
Insect Resources Laboratory, Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, Taejon, South Korea.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|