Linked Life Data

9923545

Source:http://linkedlifedata.com/resource/pubmed/id/9923545

Statements in which the resource exists.
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pubmed-article:9923545pubmed:abstractTextThe human medulloblastoma cell line D283 Med (4-HCR), a line resistant to 4-hydroperoxycyclophosphamide (4-HC), displays enhanced repair of DNA interstrand crosslinks induced by phosphoramide mustard. D283 Med (4-HCR) cells are cross-resistant to 1,3-bis(2-chloroethyl)- -nitrosourea, but partial sensitivity is restored after elevated levels of O6-alkylguanine-DNA alkyltransferase (AGT) are depleted by O6-benzylguanine (O6-BG). Studies were conducted to define the activity of 4-HC and 4-hydroperoxydidechlorocyclophosphamide against D283 Med (4-HCR) after AGT is depleted by O6-BG.lld:pubmed
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pubmed-article:9923545pubmed:articleTitleModulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.lld:pubmed
pubmed-article:9923545pubmed:affiliationDepartment of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.lld:pubmed
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pubmed-article:9923545pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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