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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-2-5
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pubmed:abstractText |
The human medulloblastoma cell line D283 Med (4-HCR), a line resistant to 4-hydroperoxycyclophosphamide (4-HC), displays enhanced repair of DNA interstrand crosslinks induced by phosphoramide mustard. D283 Med (4-HCR) cells are cross-resistant to 1,3-bis(2-chloroethyl)- -nitrosourea, but partial sensitivity is restored after elevated levels of O6-alkylguanine-DNA alkyltransferase (AGT) are depleted by O6-benzylguanine (O6-BG). Studies were conducted to define the activity of 4-HC and 4-hydroperoxydidechlorocyclophosphamide against D283 Med (4-HCR) after AGT is depleted by O6-BG.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0344-5704
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pubmed:author |
pubmed-author:BignerD DDD,
pubmed-author:BrentT PTP,
pubmed-author:BullochKK,
pubmed-author:ColvinO MOM,
pubmed-author:DolanM EME,
pubmed-author:DonyCC,
pubmed-author:FriedmanH SHS,
pubmed-author:JohnsonS PSP,
pubmed-author:KeirSS,
pubmed-author:KilbornCC,
pubmed-author:LoktionovaN ANA,
pubmed-author:LudemanSS,
pubmed-author:ModrichPP,
pubmed-author:MoschelR CRC,
pubmed-author:PeggA EAE,
pubmed-author:StruckRR
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
80-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9923545-Animals,
pubmed-meshheading:9923545-Antineoplastic Agents, Alkylating,
pubmed-meshheading:9923545-CHO Cells,
pubmed-meshheading:9923545-Cerebellar Neoplasms,
pubmed-meshheading:9923545-Cricetinae,
pubmed-meshheading:9923545-Cyclophosphamide,
pubmed-meshheading:9923545-DNA, Neoplasm,
pubmed-meshheading:9923545-Drug Resistance, Neoplasm,
pubmed-meshheading:9923545-Female,
pubmed-meshheading:9923545-Humans,
pubmed-meshheading:9923545-Male,
pubmed-meshheading:9923545-Medulloblastoma,
pubmed-meshheading:9923545-Mice,
pubmed-meshheading:9923545-Mice, Nude,
pubmed-meshheading:9923545-Neoplasm Transplantation,
pubmed-meshheading:9923545-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:9923545-Transfection,
pubmed-meshheading:9923545-Transplantation, Heterologous,
pubmed-meshheading:9923545-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
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pubmed:affiliation |
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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