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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-2-5
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pubmed:abstractText |
Studying the metabolism of cytotoxic drugs has become increasingly necessary to predict clinically significant drug-drug interactions and to understand the basis of interindividual variations in the pharmacokinetics of anticancer agents. The aim of this study was to determine the feasibility of using V79 Chinese hamster fibroblasts, which are stably transfected with cytochrome P450 (CYP) cDNAs, to study the metabolism of cytotoxic drugs in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2B1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Ifosfamide,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel
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pubmed:status |
MEDLINE
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pubmed:issn |
0344-5704
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-67
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9923542-Animals,
pubmed-meshheading:9923542-Antineoplastic Agents,
pubmed-meshheading:9923542-Antineoplastic Agents, Alkylating,
pubmed-meshheading:9923542-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9923542-Cell Line,
pubmed-meshheading:9923542-Coculture Techniques,
pubmed-meshheading:9923542-Cricetinae,
pubmed-meshheading:9923542-Cricetulus,
pubmed-meshheading:9923542-Cyclophosphamide,
pubmed-meshheading:9923542-Cytochrome P-450 CYP2B1,
pubmed-meshheading:9923542-Cytochrome P-450 CYP3A,
pubmed-meshheading:9923542-Cytochrome P-450 Enzyme System,
pubmed-meshheading:9923542-DNA, Complementary,
pubmed-meshheading:9923542-Humans,
pubmed-meshheading:9923542-Ifosfamide,
pubmed-meshheading:9923542-Mixed Function Oxygenases,
pubmed-meshheading:9923542-Paclitaxel
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pubmed:year |
1999
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pubmed:articleTitle |
Use of V79 cells with stably transfected cytochrome P450 cDNAs in studying the metabolism and effects of cytotoxic drugs.
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pubmed:affiliation |
Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA. philipp@kci.wayne.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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