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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1999-3-22
|
| pubmed:abstractText |
Detection of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV)/human herpesvirus (HHV-8) has been reported frequently in patients with KS associated with acquired immunodeficiency syndrome (AIDS). We examined the presence of the KSHV sequence in 8 HIV-positive patients comprising 5 with KS, 2 with syphilis, 1 with prurigo, and 2 HIV-negative patients with angiosarcoma. Using the polymerase chain reaction, we observed amplification of a DNA fragment of the expected size in 4 patients with KS. Sequencing analysis of the amplified fragments revealed several base substitutions upon comparison with the originally reported sequence. Our results support the hypothesis of a pathogenic role of KSHV in the development of skin lesions in HIV-positive patients with KS, and the sequences of KSHV DNA fragments isolated in this study also demonstrated strain diversity similar to that reported previously.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1167-1122
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
13-6
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9920979-AIDS-Related Opportunistic Infections,
pubmed-meshheading:9920979-Adult,
pubmed-meshheading:9920979-Aged,
pubmed-meshheading:9920979-Aged, 80 and over,
pubmed-meshheading:9920979-Base Sequence,
pubmed-meshheading:9920979-DNA, Viral,
pubmed-meshheading:9920979-DNA Fragmentation,
pubmed-meshheading:9920979-Female,
pubmed-meshheading:9920979-Genetic Variation,
pubmed-meshheading:9920979-Herpesvirus 8, Human,
pubmed-meshheading:9920979-Humans,
pubmed-meshheading:9920979-Male,
pubmed-meshheading:9920979-Middle Aged,
pubmed-meshheading:9920979-Molecular Sequence Data,
pubmed-meshheading:9920979-Point Mutation,
pubmed-meshheading:9920979-Polymerase Chain Reaction,
pubmed-meshheading:9920979-Sarcoma, Kaposi,
pubmed-meshheading:9920979-Sequence Alignment,
pubmed-meshheading:9920979-Skin Neoplasms
|
| pubmed:articleTitle |
Detection and sequence diversity of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8) DNA.
|
| pubmed:affiliation |
Department of Dermatology, Yokohama City, University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
|
| pubmed:publicationType |
Journal Article
|