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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1999-3-1
|
| pubmed:databankReference | |
| pubmed:abstractText |
Malignant rhabdoid tumors (MRTs) are rare, pediatric soft-tissue tumors. Homozygous deletions at chromosome 22q11.2 are a recurrent cytogenetic characteristic of MRTs, an indication that this locus may harbor one or more genes conferring tumor-suppressor activity. We constructed a deletion map of the relevant part of 22q11.2 from a panel of seven MRT cell lines, and isolated a novel gene from the center of the region. As it showed a high degree of sequence homology to genes of the Rab family, we designated it Rab36. The protein encoded by Rab36 was localized at the Golgi body. Sequencing of Rab36 cDNAs from three cell lines that retained at least one allele of this gene revealed no nonsense or frameshift mutations. Experiments to induce over-expression of Rab36 by transfection to an MRT cell line similarly failed to justify designation of this gene as a tumor suppressor that would contribute to tumorigenesis by a loss-of-function mechanism.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1999 Academic Press.
|
| pubmed:issnType |
Print
|
| pubmed:day |
27
|
| pubmed:volume |
254
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
594-600
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9920784-Amino Acid Sequence,
pubmed-meshheading:9920784-Animals,
pubmed-meshheading:9920784-Base Sequence,
pubmed-meshheading:9920784-Blotting, Northern,
pubmed-meshheading:9920784-COS Cells,
pubmed-meshheading:9920784-Carrier Proteins,
pubmed-meshheading:9920784-Cloning, Molecular,
pubmed-meshheading:9920784-DNA, Complementary,
pubmed-meshheading:9920784-Gene Deletion,
pubmed-meshheading:9920784-Genetic Vectors,
pubmed-meshheading:9920784-Homozygote,
pubmed-meshheading:9920784-Humans,
pubmed-meshheading:9920784-Immunohistochemistry,
pubmed-meshheading:9920784-Molecular Sequence Data,
pubmed-meshheading:9920784-Phosphoproteins,
pubmed-meshheading:9920784-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:9920784-Rhabdoid Tumor,
pubmed-meshheading:9920784-Sequence Homology, Amino Acid,
pubmed-meshheading:9920784-Tumor Cells, Cultured,
pubmed-meshheading:9920784-rab GTP-Binding Proteins
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors.
|
| pubmed:affiliation |
Laboratory of Genome Medicine, University of Tokyo, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|