Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1999-2-3
|
pubmed:abstractText |
To investigate cortical bone composition and the role of the insulin-like growth factor (IGF) system in active acromegaly, iliac crest bone biopsies were obtained from 15 patients (3 women and 12 men), aged 21-64 yr (mean, 45.6 yr), and 25 age- and sex-matched controls (8 women and 17 men), aged 22-66 yr (mean, 44.6 yr). Levels of IGF-I, IGF-II, IGF-binding protein-3 (IGFBP-3), IGFBP-5, and total protein were determined in extracts obtained after ethylenediamine tetraacetate and guanidine hydrochloride extraction. Osteocalcin and calcium were determined in extracts after HCl hydrolysis. Cortical bone contents of IGF-I, IGF-II, and IGFBP-5 were significantly elevated in the acromegalic patients compared with control values [91% (P < 0.001), 44% (P < 0.04), and 115% (P < 0.004), respectively]. There was no significant difference in IGFBP-3, osteocalcin, protein, and calcium between patients and controls. This study suggests that the increased levels of growth factors in cortical bone from acromegalics is a reflection of local production, secondary to a chronic systemic excess of GH and IGF-I.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Somatomedins
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0021-972X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
84
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
123-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9920071-Acromegaly,
pubmed-meshheading:9920071-Adult,
pubmed-meshheading:9920071-Age Factors,
pubmed-meshheading:9920071-Aged,
pubmed-meshheading:9920071-Bone and Bones,
pubmed-meshheading:9920071-Female,
pubmed-meshheading:9920071-Humans,
pubmed-meshheading:9920071-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:9920071-Insulin-Like Growth Factor Binding Protein 5,
pubmed-meshheading:9920071-Male,
pubmed-meshheading:9920071-Middle Aged,
pubmed-meshheading:9920071-Osteocalcin,
pubmed-meshheading:9920071-Somatomedins
|
pubmed:year |
1999
|
pubmed:articleTitle |
Increased cortical bone content of insulin-like growth factors in acromegalic patients.
|
pubmed:affiliation |
Department of Endocrinology, National University Hospital, Oslo, Norway.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|