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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-3-25
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pubmed:databankReference |
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pubmed:abstractText |
The antibiotic TA of Myxococcus xanthus is synthesized through a type I polyketide synthase mechanism. Previous studies have indicated that several genes essential for TA production are clustered within a 40-kb region and are transcriptionally co-regulated. In this study, we report the genetic analysis of the first gene in the TA gene cluster, identified as a NusG-like transcription anti-terminator. Functional analysis of this NusG-like anti-terminator gene by specific gene disruption confirms that it is essential for TA production but not for normal growth and development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0378-1097
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-7
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:9919671-Amino Acid Sequence,
pubmed-meshheading:9919671-Anti-Bacterial Agents,
pubmed-meshheading:9919671-Bacterial Proteins,
pubmed-meshheading:9919671-Escherichia coli Proteins,
pubmed-meshheading:9919671-Gene Deletion,
pubmed-meshheading:9919671-Gene Expression Regulation, Bacterial,
pubmed-meshheading:9919671-Genes, Regulator,
pubmed-meshheading:9919671-Macrolides,
pubmed-meshheading:9919671-Molecular Sequence Data,
pubmed-meshheading:9919671-Multigene Family,
pubmed-meshheading:9919671-Myxococcus xanthus,
pubmed-meshheading:9919671-Peptide Elongation Factors,
pubmed-meshheading:9919671-Physical Chromosome Mapping,
pubmed-meshheading:9919671-Ribosomal Proteins,
pubmed-meshheading:9919671-Sequence Alignment,
pubmed-meshheading:9919671-Sequence Analysis, DNA,
pubmed-meshheading:9919671-Transcription, Genetic,
pubmed-meshheading:9919671-Transcription Factors
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pubmed:year |
1999
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pubmed:articleTitle |
A NusG-like transcription anti-terminator is involved in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus.
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pubmed:affiliation |
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ruamat Aviv, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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