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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-2-23
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pubmed:databankReference |
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pubmed:abstractText |
The DYRK1A gene on human chromosome 21 encodes a protein kinase presumed to be involved in the pathogenesis of mental retardation in Down's syndrome. Here we describe a highly similar homolog, DYRK1B, which is, in contrast to DYRK1A, predominately expressed in muscle and testis. The human DYRK1B gene was mapped to chromosome 19 (19q12-13.11) by radiation hybrid analysis. The amino acid sequences of DYRK1A and DYRK1B are 84% identical in the N-terminus and the catalytic domain but show no extended sequence similarity in the C-terminal region. DYRK1B contains all motifs characteristic for the DYRK family of protein kinases. In addition, the sequence comprises a bipartite nuclear localization motif. A green fluorescent protein (GFP) fusion protein of DYRK1B was found mainly in the nucleus of transfected COS-7 cells. These data suggest that DYRK1B is a muscle- and testis-specific isoform of DYRK1A and is involved in the regulation of nuclear functions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
254
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
474-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9918863-Amino Acid Sequence,
pubmed-meshheading:9918863-Animals,
pubmed-meshheading:9918863-Base Sequence,
pubmed-meshheading:9918863-COS Cells,
pubmed-meshheading:9918863-Cell Nucleus,
pubmed-meshheading:9918863-Chromosome Mapping,
pubmed-meshheading:9918863-Chromosomes, Human, Pair 19,
pubmed-meshheading:9918863-Cloning, Molecular,
pubmed-meshheading:9918863-Green Fluorescent Proteins,
pubmed-meshheading:9918863-Humans,
pubmed-meshheading:9918863-Luminescent Proteins,
pubmed-meshheading:9918863-Male,
pubmed-meshheading:9918863-Molecular Sequence Data,
pubmed-meshheading:9918863-Muscle, Skeletal,
pubmed-meshheading:9918863-Protein Kinases,
pubmed-meshheading:9918863-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9918863-Protein-Tyrosine Kinases,
pubmed-meshheading:9918863-Recombinant Fusion Proteins,
pubmed-meshheading:9918863-Recombinant Proteins,
pubmed-meshheading:9918863-Sequence Alignment,
pubmed-meshheading:9918863-Sequence Homology, Amino Acid,
pubmed-meshheading:9918863-Testis,
pubmed-meshheading:9918863-Transfection
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pubmed:year |
1999
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pubmed:articleTitle |
Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases.
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pubmed:affiliation |
Institut für Pharmakologie und Toxikologie, RWTH Aachen, Aachen, D-52057, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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