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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-2-22
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pubmed:abstractText |
Using an ethnomedical-based drug discovery program, two previously unknown compounds (SP-18904 and SP-18905) from Pycnanthus angolensis were isolated that lower glucose concentrations in mouse models of type 2 diabetes. SP-18904 and SP-18905 are terpenoid-type quinones that significantly lowered plasma glucose concentration (p <.05) when given orally to either ob/ob or db/db mice, both of which are hyperglycemic and hyperinsulinemic. The antihyperglycemic actions of SP-18904 and SP-18905 were associated with significant decreases in plasma insulin concentrations (p <.05), suggesting that both compounds lowered glucose by enhancing insulin-mediated glucose uptake. This was supported by the insulin suppression test in ob/ob mice. Studies in hyperglycemic, insulin-deficient mice and in vitro experiments on 3T3-L1 adipocytes further supported this conclusion. As such, these two terpenoid-type quinones represent a new class of compounds of potential use in the treatment of type 2 diabetes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-3565
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pubmed:author |
pubmed-author:CarlsonT JTJ,
pubmed-author:CheungJJ,
pubmed-author:ClarkJ PJP,
pubmed-author:FortD MDM,
pubmed-author:HectorR FRF,
pubmed-author:JoladS DSD,
pubmed-author:KindS SSS,
pubmed-author:LaprescaPP,
pubmed-author:LumHH,
pubmed-author:MendezC DCD,
pubmed-author:ReavenG MGM,
pubmed-author:TsaiJJ,
pubmed-author:UbillasR PRP,
pubmed-author:YevichE MEM
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pubmed:issnType |
Print
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
529-34
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9918555-Adipocytes,
pubmed-meshheading:9918555-Animals,
pubmed-meshheading:9918555-Blood Glucose,
pubmed-meshheading:9918555-Cells, Cultured,
pubmed-meshheading:9918555-Diabetes Mellitus, Experimental,
pubmed-meshheading:9918555-Diabetes Mellitus, Type 2,
pubmed-meshheading:9918555-Disease Models, Animal,
pubmed-meshheading:9918555-Eating,
pubmed-meshheading:9918555-Hypoglycemic Agents,
pubmed-meshheading:9918555-Insulin,
pubmed-meshheading:9918555-Male,
pubmed-meshheading:9918555-Mice,
pubmed-meshheading:9918555-Mice, Inbred C57BL,
pubmed-meshheading:9918555-Naphthoquinones,
pubmed-meshheading:9918555-Plant Extracts,
pubmed-meshheading:9918555-Plants, Medicinal,
pubmed-meshheading:9918555-Trees
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pubmed:year |
1999
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pubmed:articleTitle |
Novel terpenoid-type quinones isolated from Pycnanthus angolensis of potential utility in the treatment of type 2 diabetes.
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pubmed:affiliation |
Shaman Pharmaceuticals, Inc., South San Francisco, California 94080- 4812, USA.
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pubmed:publicationType |
Journal Article
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