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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1999-3-18
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pubmed:abstractText |
The effect of progesterone (P) on pancreatic islet-cell proliferation and function of cyclic and pregnant rats was investigated in vivo. Silastic tubes containing P were inserted s.c. in cyclic rats for 7 or 14 days and in pregnant rats from day 7 to 14, from day 14 to 21 or from day 7 to 21 of pregnancy. 5-Bromo-2-deoxyuridine (BrdU) was infused during the last 24h of the treatment; the proportion of dividing islet-cells was determined in pancreatic sections, which were immunostained for BrdU. Islet-cell function was determined by measuring glucose and insulin response to a standard intravenous glucose challenge. P treatment increased P and 20alpha-dihydroprogesterone (20alpha-OHP) levels in cyclic rats; in pregnant rats, only the plasma levels of 20alpha-OHP were elevated. Both 7 and 14 days of P treatment stimulated islet-cell proliferation in cyclic rats. In pregnant rats, P treatment increased islet-cell proliferation on day 14, but not on day 21 after either 7 or 14 days of P treatment. P did not affect plasma lactogenic activity in pregnant rats; plasma concentrations of prolactin were decreased after 14 days of P treatment in cyclic rats, but were not affected in pregnant rats. P treatment had no effect on glucose tolerance and glucose-stimulated insulin secretion in any of the groups. It was concluded that: 1. in vivo P stimulates islet-cell proliferation, but does not affect islet-cell function, 2. the stimulatory effects of P are indirect and possibly mediated by the P metabolite 20alpha-OHP and 3. at the end of gestation, stimulation of islet-cell proliferation is inhibited by some factor, which is not identical to P.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0018-5043
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649-55
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9918380-Algestone,
pubmed-meshheading:9918380-Animals,
pubmed-meshheading:9918380-Cell Division,
pubmed-meshheading:9918380-Eating,
pubmed-meshheading:9918380-Estrus,
pubmed-meshheading:9918380-Female,
pubmed-meshheading:9918380-Gestational Age,
pubmed-meshheading:9918380-Glucose Tolerance Test,
pubmed-meshheading:9918380-Insulin,
pubmed-meshheading:9918380-Islets of Langerhans,
pubmed-meshheading:9918380-Pregnancy,
pubmed-meshheading:9918380-Progesterone,
pubmed-meshheading:9918380-Prolactin,
pubmed-meshheading:9918380-Rats,
pubmed-meshheading:9918380-Rats, Wistar,
pubmed-meshheading:9918380-Time Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Proliferation of pancreatic islet-cells in cyclic and pregnant rats after treatment with progesterone.
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pubmed:affiliation |
Department of Obstetrics & Gynaecology, University of Groningen, The Netherlands. a.g.nieuwenhuizen@med.rug.nl
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pubmed:publicationType |
Journal Article
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