Linked Life Data

9917421

Source:http://linkedlifedata.com/resource/pubmed/id/9917421

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-3-11
pubmed:abstractText
Sodium thiopental, as other amphiphilic molecules, interacts with the membrane by inserting into the lipid bilayer and causing alterations of the membrane properties such as curvature and hypotonic lysis resistance. But can it modify the mechanical properties of the membrane? In the present work it was observed that sodium thiopental affected the membrane rheological properties by improving erythrocyte deformability; this effect resulted from a reduction of both the elastic modulus and surface viscosity. In erythrocytes devoid of sialic acid after treatment with neuraminidase, sodium thiopental membrane concentration was significantly higher than in normal cells, suggesting that drug access to the lipid bilayer be facilitated by the absence of the steric and electrostatic barrier of the glycocalyx negative charges. From a rheological point of view, desialated and normal cells showed the same response to the anesthetic as regards elastic modulus but in opposite direction if surface viscosity was considered. This finding supports the hypothesis that sodium thiopental molecules enter the bilayer of desialated cells in a higher proportion, as compared to the normal erythrocyte, promoting a disorganization that results in a greater inner friction. The changes in the rheological parameters, triggered by sodium thiopental, could be attributed to the bilayer contribution to the membrane mechanical properties, either directly or through interaction between the bilayer and the cytoskeleton.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1079-9796
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
552-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Effects of an amphipathic drug on the rheological properties of the cell membrane.
pubmed:affiliation
Cátedra de Biofísica. Facultad de Ciencias Médicas. Universidad Nacional de Rosario. Sante Fe 3100 (2000). Rosario República Argentina.
pubmed:publicationType
Journal Article