rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1999-3-10
|
pubmed:abstractText |
Discorhabdin P (1), a new discorhabdin analogue, has been isolated from a deep-water marine sponge of the genus Batzella. Discorhabdin P (1) inhibited the phosphatase activity of calcineurin and the peptidase activity of CPP32. It also showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of discorhabdin P (1) are described.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calcineurin,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Quinones,
http://linkedlifedata.com/resource/pubmed/chemical/Spiro Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazepines
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0163-3864
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
62
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
173-5
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:9917313-Animals,
pubmed-meshheading:9917313-Antineoplastic Agents,
pubmed-meshheading:9917313-Calcineurin,
pubmed-meshheading:9917313-Caspase 3,
pubmed-meshheading:9917313-Caspases,
pubmed-meshheading:9917313-Crystallography, X-Ray,
pubmed-meshheading:9917313-Enzyme Inhibitors,
pubmed-meshheading:9917313-Humans,
pubmed-meshheading:9917313-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9917313-Mice,
pubmed-meshheading:9917313-Molecular Structure,
pubmed-meshheading:9917313-Porifera,
pubmed-meshheading:9917313-Quinones,
pubmed-meshheading:9917313-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:9917313-Spiro Compounds,
pubmed-meshheading:9917313-Thiazepines,
pubmed-meshheading:9917313-Tumor Cells, Cultured
|
pubmed:year |
1999
|
pubmed:articleTitle |
Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
|
pubmed:affiliation |
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, Florida 34946, USA. sgunaseker@hbio.edu
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|