Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-2-11
pubmed:abstractText
In earlier experiments, exogenous administration of secretory leukocyte protease inhibitor (SLPI) suppressed acute lung injury induced by deposition of IgG immune complexes. In the current studies we examined the mechanism of the protective effects of SLPI in this model. The presence of SLPI in the IgG immune complex-model of lung injury reduced the increase in extravascular leakage of 125I-albumin, the intensity of up-regulation of lung vascular intercellular adhesion molecule-1, and the numbers of neutrophils accumulating in the lung. The presence of SLPI caused greatly reduced activation (ie, nuclear translocation) of the transcription nuclear factor-kappaB (NF-kappaB) in lung cells but did not suppress activation of lung mitogen-activated protein kinase. SLPI did not alter NF-kappaB activation in alveolar macrophages harvested 30 minutes after initiation of lung inflammation. In the presence of SLPI, content of tumor necrosis factor-alpha, CXC chemokines, and C5a in bronchoalveolar fluids was unaffected. In the inflamed lungs, inhibition of NF-kappaB activation by SLPI was associated with elevated levels of lung IkappaBbeta (but not IkappaBalpha) protein in the absence of elevated mRNA for IkappaBbeta. When instilled into normal lung, SLPI also caused similar changes (increases) in lung IkappaBbeta. Finally, in the lung inflammatory model used, the presence of anti-SLPI caused accentuated activation of NF-kappaB. These data confirm the anti-inflammatory effect of SLPI in lung and point to a mechanism of anti-inflammatory effects of SLPI. SLPI appears to function as an endogenous regulator of lung inflammation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-1422741, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-1717513, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-1826836, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-2299266, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-2531759, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-2613293, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-3706899, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-3782828, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-4277008, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-5134887, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-6312841, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-6453163, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-7542214, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-7615818, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-7685152, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-7769236, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-7804796, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-7867065, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-7901193, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-7903451, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-7946401, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-8427705, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-8717528, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9039268, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9062347, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9092533, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9120305, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9242546, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9261902, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9317147, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9366558, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9382799, http://linkedlifedata.com/resource/pubmed/commentcorrection/9916938-9588901
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-47
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Inhibition of NF-kappaB activation and augmentation of IkappaBbeta by secretory leukocyte protease inhibitor during lung inflammation.
pubmed:affiliation
Department of Surgery, University of Louisville School of Medicine, Kentucky, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't