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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1999-4-7
|
| pubmed:abstractText |
The HLA-A*02 allele is the most heterogeneous allele at HLA-A locus with 22 different subtypes so far identified. All of these subtype polymorphisms are located in alpha 1 and alpha 2 domains which are responsible for peptide biding and HLA restricted recognition by T-cell receptor. The aim of the present study was to determine the frequency of different HLA-A*02 alleles in 33 healthy unrelated Croatians. HLA-A*02 subtyping has also been retrospectively performed in 2 recipient-unrelated donor pairs and in 4 recipient-HLA phenotypically identical parent pairs. All subjects, previously typed as HLA-A2 by serology were tested using HLA-A*02 ARMS-PCR kit which discriminates 17 different A*02 alleles. Among 17 A*02 alleles we have found 4 different A*02 subtypes in healthy unrelated Croatians. The most frequent A*02 allele was A*0201 (84%). The frequency of the remaining A*02 alleles were as follows: A*0205 (3%), A*0207 (6%) and A*0213 (6%). Among 6 tested bone-marrow transplantation (BMT) pairs, only one has been found to be A*02 subtype incompatible (A*0201/A*0205). Four different A*02 alleles are found in Croatian population with the predominance of A*0201. However these results suggest that A*02 subtyping is also necessary for optimal matching of HLA-A*02 positive donor-recipient pairs in HLA incompatible BMT.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0268-3369
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22 Suppl 4
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S27-30
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:9916628-Alleles,
pubmed-meshheading:9916628-Bone Marrow Transplantation,
pubmed-meshheading:9916628-Croatia,
pubmed-meshheading:9916628-Female,
pubmed-meshheading:9916628-Gene Frequency,
pubmed-meshheading:9916628-HLA-A Antigens,
pubmed-meshheading:9916628-Histocompatibility Testing,
pubmed-meshheading:9916628-Humans,
pubmed-meshheading:9916628-Male,
pubmed-meshheading:9916628-Tissue Donors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Implication of molecular analysis of HLA-A*02 subtyping for unrelated bone-marrow donor selection.
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| pubmed:affiliation |
Tissue Typing Centre, University Hospital Zagreb, Croatia.
|
| pubmed:publicationType |
Journal Article
|