Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-3-10
pubmed:abstractText
Familial hemophagocytic lymphohistiocytosis (FHL), also known as familial erythrophagocytic lymphohistiocytosis and familial histiocytic reticulosis, is a rare autosomal recessive disorder of early childhood characterized by excessive immune activation. Linkage of the disease gene to an approximately 7.8-cM region between markers D9S1867 and D9S1790 at 9q21.3-22 was identified by homozygosity mapping in four inbred FHL families of Pakistani descent with a combined maximum multipoint LOD score of 6.05. This is the first genetic locus to be described in FHL. However, homozygosity by descent across this interval could not be demonstrated in an additional affected kindred of Arab origin, whose maximum multipoint LOD score was -0.12. The combined sample revealed significant evidence for linkage to 9q markers (LOD score with heterogeneity, 5.00). Identification of the gene(s) involved in the pathogenesis of FHL will contribute to an understanding of the control of T-lymphocyte and macrophage activation, which is central to homeostasis in the immune system.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-13008468, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-14081488, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-1436057, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-1505026, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-1954380, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-1992521, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-2058392, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-2070059, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-2153036, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-2445462, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-2786434, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-2884728, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-3355209, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-6354720, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-6368780, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-7115950, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-7481803, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-7545953, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-7819097, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-7920657, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8251408, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8307588, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8324828, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8400285, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8600387, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8651312, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8697818, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8703807, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8717042, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8780871, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8806292, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8888739, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-8896560, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-9063426, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-9140409, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-9143683, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-9166851, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-9207796, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-9212839, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-9519782, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-9545394, http://linkedlifedata.com/resource/pubmed/commentcorrection/9915955-9630231
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-71
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Localization of a gene for familial hemophagocytic lymphohistiocytosis at chromosome 9q21.3-22 by homozygosity mapping.
pubmed:affiliation
Department of Haematological Medicine, King's College School of Medicine and Dentistry, Denmark Hill, London SE5 9PJ, United Kingdom.
pubmed:publicationType
Journal Article