Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1977-1-25
|
| pubmed:abstractText |
A gas chromatographic mass spectrometric method for the quantitative determination of imipramine and its N-demethylated metabolite desipramine in plasma samples at the nanogram level is reported. The method involves derivatization of the extracted drugs with trifluoroacetylimidazole, a mild derivatizing reagent. Specificity is provided by selected ion recording of the [M + H]+ ions, formed upon chemical ionization with methane as reagent gas. Quantitation is achieved by stable isotope dilution techniques, using deuterium labeled analogs, prepared by acid-catalyzed exchange, as internal standards. Data on patient samples are presented.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0306-042X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
110-6
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:990418-Chemical Phenomena,
pubmed-meshheading:990418-Chemistry,
pubmed-meshheading:990418-Chromatography, Gas,
pubmed-meshheading:990418-Desipramine,
pubmed-meshheading:990418-Deuterium,
pubmed-meshheading:990418-Humans,
pubmed-meshheading:990418-Imipramine,
pubmed-meshheading:990418-Mass Spectrometry,
pubmed-meshheading:990418-Methods
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Simultaneous measurement of imipramine and desipramine by selected ion recording with deuterated internal standards.
|
| pubmed:publicationType |
Journal Article
|