Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1999-3-11
|
pubmed:abstractText |
The severity of systemic infection with the yeast Candida albicans has been shown to be under complex genetic control. C57/L mice carry an allele that is associated with an increase in tissue destruction when compared with C57Bl/6 mice; however, the gene affects only the severity of tissue lesions, and does not influence the magnitude of the fungal burden in either kidney or brain. Studies in [C57/LxC57Bl/6]F1 hybrid mice, and [C57/LxC57Bl/6]F1xC57/L backcross mice, demonstrated that the gene behaves as a simple Mendelian co-dominant.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0882-4010
|
pubmed:author | |
pubmed:copyrightInfo |
Copyright 1998 Academic Press
|
pubmed:issnType |
Print
|
pubmed:volume |
25
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
349-52
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9895274-Alleles,
pubmed-meshheading:9895274-Animals,
pubmed-meshheading:9895274-Brain Diseases,
pubmed-meshheading:9895274-Candida albicans,
pubmed-meshheading:9895274-Candidiasis,
pubmed-meshheading:9895274-Genes, Fungal,
pubmed-meshheading:9895274-Kidney Diseases,
pubmed-meshheading:9895274-Mice,
pubmed-meshheading:9895274-Mice, Inbred C57BL,
pubmed-meshheading:9895274-Sensitivity and Specificity
|
pubmed:year |
1998
|
pubmed:articleTitle |
A second Candida albicans resistance gene (Carg2) regulates tissue damage, but not fungal clearance, in sub-lethal murine systemic infection.
|
pubmed:affiliation |
School of Dentistry, University of Queensland, Brisbane, Qld., Australia.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|