Linked Life Data

9892851

Source:http://linkedlifedata.com/resource/pubmed/id/9892851

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pubmed-article:9892851pubmed:abstractTextEstrogens modulate the density of opioid receptors in selected brain areas; however, it is not clear whether they exert such an effect directly on the cells which express the opioid receptors. Therefore, we analyzed the binding of [3H]-diprenorphine in human neuroblastoma cells stably transfected with the estrogen receptor cDNA (SK-ER3 cell line). A 16-hour exposure of these cells with 1 nM 17beta-estradiol induces a progressive morphological differentiation which appears clearly established 6 days after the suspension of the treatment. The binding of [3H]-diprenorphine was then measured immediately after the exposure to 17beta-estradiol (16 h) as well as 6 days later. The results shows that the number of opioid receptors in SK-ER3 cells is unaffected at 16 h but appears significantly reduced at 6 days. This effect is blocked by the estrogen antagonist ICI-182780, and is coincident to a decrease of the inhibitory effect of morphine on cyclic AMP accumulation. Binding experiments performed using selective ligands suggest that the micro subclass of opioid receptors is down-regulated by estradiol in SK-ER3 cells.lld:pubmed
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pubmed-article:9892851pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9892851pubmed:articleTitleDecrease of the number of opioid receptors and of the responsiveness to morphineduring neuronal differentiation induced by 17beta-estradiol in estrogen receptor-transfected neuroblastoma cells (SK-ER3).lld:pubmed
pubmed-article:9892851pubmed:affiliationDepartment of Endocrinology, Institute of Pharmacological Sciences, University of Milan, Italy. maggir@imiucca.csi.unimi.itlld:pubmed
pubmed-article:9892851pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9892851pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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