rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1999-3-25
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pubmed:abstractText |
The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal. These essential peptide motifs have now been shown to function by accessing cellular signal-mediated pathways for nuclear import and nuclear export. HIV-1 Rev therefore represents an excellent system with which to study aspects of transport across the nuclear envelope.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, rev,
http://linkedlifedata.com/resource/pubmed/chemical/Karyopherins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/exportin 1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/rev Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:issn |
0066-4227
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
491-532
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9891806-Alternative Splicing,
pubmed-meshheading:9891806-Amino Acid Sequence,
pubmed-meshheading:9891806-Carrier Proteins,
pubmed-meshheading:9891806-Cell Nucleus,
pubmed-meshheading:9891806-Gene Expression Regulation, Viral,
pubmed-meshheading:9891806-Gene Products, rev,
pubmed-meshheading:9891806-HIV Infections,
pubmed-meshheading:9891806-HIV-1,
pubmed-meshheading:9891806-Humans,
pubmed-meshheading:9891806-Karyopherins,
pubmed-meshheading:9891806-Molecular Sequence Data,
pubmed-meshheading:9891806-RNA, Messenger,
pubmed-meshheading:9891806-RNA, Viral,
pubmed-meshheading:9891806-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:9891806-Trans-Activators,
pubmed-meshheading:9891806-rev Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1998
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pubmed:articleTitle |
The HIV-1 Rev protein.
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pubmed:affiliation |
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6148, USA. pollard@hhmi.upenn.edu
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pubmed:publicationType |
Journal Article,
Review
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