Linked Life Data

9891455

Source:http://linkedlifedata.com/resource/pubmed/id/9891455

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6A
pubmed:dateCreated
1999-2-11
pubmed:abstractText
Parity in rats results in protection from methylnitrosourea (MNU)-induced mammary cancer. Our goal was to determine if systemic alterations in the mammary gland environment after a full-term pregnancy rendered the parous rat an inadequate host for promotion of initiated mammary epithelial cells to become cancerous. Lewis rat MNU-treated mammary epithelial cells were transplanted into uniparous (UP), age-matched virgin (AMV) (both 130-150 d), or young virgin (YV) (50-60 d) syngeneic hosts to examine if differences in the systemic environments of the three hosts had an effect on hyperplasia and cancer formation. More transplants in YV and AMV hosts contained hyperplasias and adenocarcinomas as compared to transplants in UP hosts. In addition, UP host transplants had significantly fewer numbers of hyperplastic lesions than transplants from the virgin hosts. The evidence presented here shows that the uniparous host environment is less supportive than that of the virgin host for hyperplasia and cancer development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4115-21
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Changes in the parous rat mammary gland environment are involved in parity-associated protection against mammary carcinogenesis.
pubmed:affiliation
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.