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rdf:type |
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lifeskim:mentions |
umls-concept:C0043041,
umls-concept:C0258432,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0851285,
umls-concept:C1166758,
umls-concept:C1421478,
umls-concept:C1421479,
umls-concept:C1552599,
umls-concept:C1565319,
umls-concept:C1704787,
umls-concept:C1853761
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pubmed:issue |
25
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pubmed:dateCreated |
1999-3-11
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pubmed:databankReference |
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pubmed:abstractText |
The actin-related proteins Arp2 and Arp3 are part of a seven-protein complex which is localized in the lamellipodia of a variety of cell types, and in actin-rich spots of unknown function. The Arp2/3 complex enhances actin nucleation and causes branching and crosslinking of actin filaments in vitro; in vivo it is thought to drive the formation of lamellipodia and to be a control center for actin-based motility. The Wiskott-Aldrich syndrome protein, WASP, is an adaptor protein implicated in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Scar1 is a member of a new family of proteins related to WASP, and it may also have a role in regulating the actin cytoskeleton. Scar1 is the human homologue of Dictyostelium Scar1, which is thought to connect G-protein-coupled receptors to the actin cytoskeleton. The mammalian Scar family contains at least four members. We have examined the relationships between WASP, Scar1, and the Arp2/3 complex.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actin-Related Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Actin-Related Protein 3,
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Actr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Actr3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Was protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Wasf1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Wiskott-Aldrich Syndrome Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wiskott-Aldrich Syndrome Protein...
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pubmed:status |
MEDLINE
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1347-56
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9889097-3T3 Cells,
pubmed-meshheading:9889097-Actin-Related Protein 2,
pubmed-meshheading:9889097-Actin-Related Protein 3,
pubmed-meshheading:9889097-Actins,
pubmed-meshheading:9889097-Animals,
pubmed-meshheading:9889097-Brain Chemistry,
pubmed-meshheading:9889097-COS Cells,
pubmed-meshheading:9889097-Cytoskeletal Proteins,
pubmed-meshheading:9889097-Cytoskeleton,
pubmed-meshheading:9889097-Cytosol,
pubmed-meshheading:9889097-Gene Expression Regulation,
pubmed-meshheading:9889097-Growth Substances,
pubmed-meshheading:9889097-Mice,
pubmed-meshheading:9889097-Microfilament Proteins,
pubmed-meshheading:9889097-Protein Binding,
pubmed-meshheading:9889097-Protein Biosynthesis,
pubmed-meshheading:9889097-Proteins,
pubmed-meshheading:9889097-Rabbits,
pubmed-meshheading:9889097-Swine,
pubmed-meshheading:9889097-Wiskott-Aldrich Syndrome Protein,
pubmed-meshheading:9889097-Wiskott-Aldrich Syndrome Protein Family
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pubmed:articleTitle |
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.
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pubmed:affiliation |
MRC-LMCB, Department of Molecular Medicine, University College London, Gower Street, London WC1E 6BT, UK. machesky@pugh.bip.bham
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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