rdf:type |
|
lifeskim:mentions |
umls-concept:C0004610,
umls-concept:C0019080,
umls-concept:C0026336,
umls-concept:C0042397,
umls-concept:C0180431,
umls-concept:C0205349,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1705294,
umls-concept:C1706817,
umls-concept:C2911692
|
pubmed:issue |
1
|
pubmed:dateCreated |
1999-2-23
|
pubmed:abstractText |
The "two-hit" theory of multiple organ dysfunction (MOD) proposes that an initial insult, such as hemorrhage (HEM), primes the host for an abnormal response to a second stress such as infection. The immunologic/inflammatory component of this theory has been well examined; however, the effects on vascular responsiveness are poorly understood. We hypothesized that HEM primes the vasculature for an altered response to a second pathophysiologic stress.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0022-4804
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright 1999 Academic Press.
|
pubmed:issnType |
Print
|
pubmed:volume |
81
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
59-64
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9889059-Acetylcholine,
pubmed-meshheading:9889059-Animals,
pubmed-meshheading:9889059-Aorta,
pubmed-meshheading:9889059-Bacteremia,
pubmed-meshheading:9889059-Blood Pressure,
pubmed-meshheading:9889059-Escherichia coli,
pubmed-meshheading:9889059-Hemorrhage,
pubmed-meshheading:9889059-Male,
pubmed-meshheading:9889059-Models, Biological,
pubmed-meshheading:9889059-Muscle Contraction,
pubmed-meshheading:9889059-Phenylephrine,
pubmed-meshheading:9889059-Rats,
pubmed-meshheading:9889059-Rats, Sprague-Dawley,
pubmed-meshheading:9889059-Vasoconstriction,
pubmed-meshheading:9889059-Vasoconstrictor Agents,
pubmed-meshheading:9889059-Vasodilation,
pubmed-meshheading:9889059-Vasodilator Agents
|
pubmed:year |
1999
|
pubmed:articleTitle |
Altered vasoconstrictor and dilator responses after a "two-hit" model of sequential hemorrhage and bacteremia.
|
pubmed:affiliation |
University of Louisville, Louisville Veterans Administration Medical Center, Louisville, Kentucky, 40292, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|