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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1999-2-22
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pubmed:abstractText |
The objective of this study was to assess the prognostic relevance of preoperative serum anti-p53 antibodies in epithelial ovarian cancer. These autoantibodies were detected with a new generation enzyme-linked immunosorbent assay in blood samples preoperatively drawn from 86 patients with this malignancy. Serum anti-p53 antibodies were found in 3 (10.0%) of the 30 patients with stage I-II and 15 (26.8%) of the 56 patients with stage III-IV epithelial ovarian cancer (P = 0.09). We assessed in detail 44 patients with stage III-IV disease who underwent six cycles of first-line platinum-based chemotherapy. A pathological complete response at second-look was achieved by none of the 15 patients with serum anti-p53 antibodies compared to 24.1% of the 29 patients without autoantibodies (P = 0.09). However, the preoperative serum anti-p53 antibody status had no prognostic relevance for progression-free survival and survival. In conclusion, the assessment of preoperative serum anti-p53 antibodies seems to have a limited clinical value in the management of patients with advanced epithelial ovarian cancer.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0090-8258
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
76-81
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9889034-Autoantibodies,
pubmed-meshheading:9889034-Female,
pubmed-meshheading:9889034-Humans,
pubmed-meshheading:9889034-Middle Aged,
pubmed-meshheading:9889034-Ovarian Neoplasms,
pubmed-meshheading:9889034-Prognosis,
pubmed-meshheading:9889034-Survival Rate,
pubmed-meshheading:9889034-Tumor Suppressor Protein p53
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pubmed:year |
1999
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pubmed:articleTitle |
Assessment of the prognostic relevance of serum anti-p53 antibodies in epithelial ovarian cancer.
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pubmed:affiliation |
Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 67, Pisa, 56127, Italy.
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pubmed:publicationType |
Journal Article
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