Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1999-4-13
pubmed:abstractText
The stimulation of the zona glomerulosa phenotype by a low sodium diet is characterised by increased expression of aldosterone synthase accompanied by increases in (pro)renin, bFGF, c-fos and c-jun gene transcription. In contrast ACTH diminishes the specific glomerulosa phenotype. The EGF related transmembrane protein preadipocyte factor 1 (Pref-1) is specifically found in the zona glomerulosa and medulla of the adult rat adrenal as well as being expressed in fetal tissue. In addition the orphan nuclear receptor SF-1/Ad4bp considered to be an important factor in fetal adrenocortical development and differentiation may also have a role in zonal differentiation in the adult. To investigate their roles, adrenals were taken from adult Wistar rats maintained on a low sodium diet or ACTH treated (enhancing or diminishing zona glomerulosa function respectively) and compared with untreated controls. Localisation of Pref-1 was carried out by immunocytochemistry using the polyclonal antibody ZOG (anti Pref-1) and of SF-1 using a rabbit antiserum to SF-1. The experimental treatment resulted in a decrease and increase in Pref-1 expression in ACTH treated and low sodium diet treated rats respectively, in accordance with changes in abundance of glomerulosa cells. SF-1 expression was expected throughout the adrenal cortex, without zonal differentiation, though somewhat decreased by ACTH treatment. Of these two factors, only Pref-1 can be considered to have a role in zonal differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Dlk1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Fushi Tarazu Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Steroidogenic Factor 1, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:issn
0743-5800
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
977-81
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9888610-Adrenal Cortex, pubmed-meshheading:9888610-Adrenocorticotropic Hormone, pubmed-meshheading:9888610-Animals, pubmed-meshheading:9888610-Cell Count, pubmed-meshheading:9888610-DNA-Binding Proteins, pubmed-meshheading:9888610-Diet, Sodium-Restricted, pubmed-meshheading:9888610-Female, pubmed-meshheading:9888610-Fushi Tarazu Transcription Factors, pubmed-meshheading:9888610-Homeodomain Proteins, pubmed-meshheading:9888610-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:9888610-Membrane Proteins, pubmed-meshheading:9888610-Rabbits, pubmed-meshheading:9888610-Rats, pubmed-meshheading:9888610-Rats, Wistar, pubmed-meshheading:9888610-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:9888610-Reference Values, pubmed-meshheading:9888610-Repressor Proteins, pubmed-meshheading:9888610-Steroidogenic Factor 1, pubmed-meshheading:9888610-Tissue Distribution, pubmed-meshheading:9888610-Transcription Factors, pubmed-meshheading:9888610-Zona Glomerulosa
pubmed:articleTitle
Pref-1, SF-1 and adrenocortical zonation.
pubmed:affiliation
Department of Biochemistry, Queen Mary and Westfield College, London, UK.
pubmed:publicationType
Journal Article