9888443

Source:http://linkedlifedata.com/resource/pubmed/id/9888443

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0014964, umls-concept:C0035316, umls-concept:C1407029, umls-concept:C1704259, umls-concept:C1705987
pubmed:issue	1
pubmed:dateCreated	1999-1-20
pubmed:abstractText	Ethambutol is an essential medication in the management of tuberculosis. However, it can cause an optic neuropathy of uncertain etiology. Ethambutol toxicity was therefore studied in rodent retinal cells, and agents that might block its toxicity were considered.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01-EY10009
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7703701
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antitubercular Agents, http://linkedlifedata.com/resource/pubmed/chemical/CM-DiI, http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Carbocyanines, http://linkedlifedata.com/resource/pubmed/chemical/EDBA, http://linkedlifedata.com/resource/pubmed/chemical/Ethambutol, http://linkedlifedata.com/resource/pubmed/chemical/Ethylenediamines, http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes, http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Memantine, http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate, http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0146-0404
pubmed:author	pubmed-author:DreyerE BEB, pubmed-author:HouxP CPC, pubmed-author:LessellEE, pubmed-author:LevinL ALA, pubmed-author:VorwerkC KCK, pubmed-author:ZurakowskiDD
pubmed:issnType	Print
pubmed:volume	40
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	190-6
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:9888443-Animals, pubmed-meshheading:9888443-Antitubercular Agents, pubmed-meshheading:9888443-Calcium, pubmed-meshheading:9888443-Carbocyanines, pubmed-meshheading:9888443-Cell Survival, pubmed-meshheading:9888443-Dose-Response Relationship, Drug, pubmed-meshheading:9888443-Ethambutol, pubmed-meshheading:9888443-Ethylenediamines, pubmed-meshheading:9888443-Excitatory Amino Acid Antagonists, pubmed-meshheading:9888443-Fluorescent Dyes, pubmed-meshheading:9888443-Glutamic Acid, pubmed-meshheading:9888443-Memantine, pubmed-meshheading:9888443-Membrane Potentials, pubmed-meshheading:9888443-Mitochondria, pubmed-meshheading:9888443-N-Methylaspartate, pubmed-meshheading:9888443-Rats, pubmed-meshheading:9888443-Retinal Ganglion Cells, pubmed-meshheading:9888443-Tetrazolium Salts, pubmed-meshheading:9888443-Thiazoles
pubmed:year	1999
pubmed:articleTitle	Ethambutol is toxic to retinal ganglion cells via an excitotoxic pathway.
pubmed:affiliation	Department of Ophthalmology, Harvard University, Boston, Massachusetts, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't