pubmed-article:9886979 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9886979 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
pubmed-article:9886979 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
pubmed-article:9886979 | lifeskim:mentions | umls-concept:C1704353 | lld:lifeskim |
pubmed-article:9886979 | lifeskim:mentions | umls-concept:C0596019 | lld:lifeskim |
pubmed-article:9886979 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
pubmed-article:9886979 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
pubmed-article:9886979 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
pubmed-article:9886979 | pubmed:issue | 1 Pt 1 | lld:pubmed |
pubmed-article:9886979 | pubmed:dateCreated | 1999-3-9 | lld:pubmed |
pubmed-article:9886979 | pubmed:abstractText | We have identified an agent (SP-303) that shows efficacy against in vivo cholera toxin-induced fluid secretion and in vitro cAMP-mediated Cl- secretion. Administration of cholera toxin to adult mice results in an increase in fluid accumulation (FA) in the small intestine (FA ratio = 0.63 vs. 1.86 in control vs. cholera toxin-treated animals, respectively). This elevation in FA induced by cholera toxin was significantly reduced (FA ratio = 0.70) in animals treated with a 100 mg/kg dose of SP-303 at the same time as the cholera treatment. Moreover, when SP-303 was administered 3 h after cholera toxin, a dose-dependent inhibition of FA levels was observed with a half-maximal inhibitory dose of 10 mg/kg. In Ussing chamber studies of Caco-2 or T84 monolayer preparations, SP-303 had a significant effect on both basal current and forskolin-stimulated Cl- current. SP-303 also induced an increase in resistance that paralleled the observed decrease in current. These data suggest that SP-303 has an inhibitory effect on cAMP-mediated Cl- and fluid secretion. Thus SP-303 may prove to be a useful broad-spectrum antidiarrheal agent. | lld:pubmed |
pubmed-article:9886979 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9886979 | pubmed:language | eng | lld:pubmed |
pubmed-article:9886979 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9886979 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:9886979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9886979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9886979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:9886979 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9886979 | pubmed:month | Jan | lld:pubmed |
pubmed-article:9886979 | pubmed:issn | 0002-9513 | lld:pubmed |
pubmed-article:9886979 | pubmed:author | pubmed-author:GabrielS ESE | lld:pubmed |
pubmed-article:9886979 | pubmed:author | pubmed-author:CarlsonTT | lld:pubmed |
pubmed-article:9886979 | pubmed:author | pubmed-author:DavenportS... | lld:pubmed |
pubmed-article:9886979 | pubmed:author | pubmed-author:RozhonE JEJ | lld:pubmed |
pubmed-article:9886979 | pubmed:author | pubmed-author:VimalVV | lld:pubmed |
pubmed-article:9886979 | pubmed:author | pubmed-author:SteagallR JRJ | lld:pubmed |
pubmed-article:9886979 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9886979 | pubmed:volume | 276 | lld:pubmed |
pubmed-article:9886979 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9886979 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9886979 | pubmed:pagination | G58-63 | lld:pubmed |
pubmed-article:9886979 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:9886979 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:9886979 | pubmed:articleTitle | A novel plant-derived inhibitor of cAMP-mediated fluid and chloride secretion. | lld:pubmed |
pubmed-article:9886979 | pubmed:affiliation | Department of Pediatric Gastroenterology, University of North Carolina, Chapel Hill, North Carolina 27599, USA. | lld:pubmed |
pubmed-article:9886979 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9886979 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:9886979 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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