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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-1-28
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pubmed:abstractText |
Central nervous system glucagon-like peptide-1-(7-36) amide (GLP-1) administration has been reported to acutely reduce food intake in the rat. We here report that repeated intracerebroventricular (i.c.v.) injection of GLP-1 or the GLP-1 receptor antagonist, exendin-(9-39), affects food intake and body weight. Daily i.c.v. injection of 3 nmol GLP-1 to schedule-fed rats for 6 days caused a reduction in food intake and a decrease in body weight of 16 +/- 5 g (P < 0.02 compared with saline-injected controls). Daily i.c.v. administration of 30 nmol exendin-(9-39) to schedule-fed rats for 3 days caused an increase in food intake and increased body weight by 7 +/- 2 g (P < 0.02 compared with saline-injected controls). Twice daily i.c.v. injections of 30 nmol exendin-(9-39) with 2.4 nmol neuropeptide Y to ad libitum-fed rats for 8 days increased food intake and increased body weight by 28 +/- 4 g compared with 14 +/- 3 g in neuropeptide Y-injected controls (P < 0.02). There was no evidence of tachyphylaxis in response to i.c.v. GLP-1 or exendin-(9-39). GLP-1 may thus be involved in the regulation of body weight in the rat.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0013-7227
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pubmed:author |
pubmed-author:AbusnanaSS,
pubmed-author:BloomS RSR,
pubmed-author:ChoiS JSJ,
pubmed-author:EdwardsC MCM,
pubmed-author:GhateiM AMA,
pubmed-author:GoldstoneA PAP,
pubmed-author:GunnII,
pubmed-author:HeathM MMM,
pubmed-author:MeeranKK,
pubmed-author:O'SheaDD,
pubmed-author:RossiMM,
pubmed-author:SmallC JCJ,
pubmed-author:SteereJJ,
pubmed-author:SunterDD,
pubmed-author:TaylorG MGM,
pubmed-author:TurtonM DMD
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pubmed:issnType |
Print
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
244-50
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:9886831-Animals,
pubmed-meshheading:9886831-Body Weight,
pubmed-meshheading:9886831-Energy Intake,
pubmed-meshheading:9886831-Glucagon,
pubmed-meshheading:9886831-Glucagon-Like Peptide 1,
pubmed-meshheading:9886831-Glucagon-Like Peptides,
pubmed-meshheading:9886831-Injections, Intraventricular,
pubmed-meshheading:9886831-Male,
pubmed-meshheading:9886831-Neurotransmitter Agents,
pubmed-meshheading:9886831-Peptide Fragments,
pubmed-meshheading:9886831-Rats,
pubmed-meshheading:9886831-Rats, Wistar
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pubmed:year |
1999
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pubmed:articleTitle |
Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat.
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pubmed:affiliation |
Imperial College School of Medicine Endocrine Unit, Hammersmith Hospital, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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