| pubmed-article:9886408 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C0599840 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C0332285 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C1509144 | lld:lifeskim |
| pubmed-article:9886408 | lifeskim:mentions | umls-concept:C0337051 | lld:lifeskim |
| pubmed-article:9886408 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9886408 | pubmed:dateCreated | 1999-1-21 | lld:pubmed |
| pubmed-article:9886408 | pubmed:abstractText | It is generally accepted that TCR alphabeta+ CD8+ T cells recognize immunogenic peptides bound to MHC-encoded class I molecules. This recognition is a major component of the cellular response mediating immune protection and recovery from viral infections and from certain intracellular bacterial infections. Here, we report two human CD8+ TCR alphabeta+ T cell lines specific for Mycobacterium tuberculosis Ags presented in the context of CD1a or CD1c Ag-presenting molecules. These T cells recognize lipid Ags and display cytotoxicity as well as strong Th cell type I cytokine responses. By extending presentation by the CD1 system to the major TCR alphabeta+ CD8+ T cell pool, this system gains wider applicability beyond the double negative subset of T cells previously shown to have this reactivity. This implies that previous assumptions about the role of CD8+ T cells in microbial immunity may require revision as the relative proportions of CD1-restricted and MHC class I-restricted CD8+ T cells are further defined. | lld:pubmed |
| pubmed-article:9886408 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9886408 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9886408 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9886408 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9886408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9886408 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9886408 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9886408 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:BeckmanE MEM | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:ModlinR LRL | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:BrennerM BMB | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:SielingP APA | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:FurlongS TST | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:RosatJ PJP | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:GrantE PEP | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:PorcelliS ASA | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:DascherC CCC | lld:pubmed |
| pubmed-article:9886408 | pubmed:author | pubmed-author:FrederiqueDD | lld:pubmed |
| pubmed-article:9886408 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9886408 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9886408 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:9886408 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9886408 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9886408 | pubmed:pagination | 366-71 | lld:pubmed |
| pubmed-article:9886408 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9886408 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9886408 | pubmed:articleTitle | CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool. | lld:pubmed |
| pubmed-article:9886408 | pubmed:affiliation | Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:9886408 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9886408 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9886408 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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