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rdf:type |
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lifeskim:mentions |
umls-concept:C0023779,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0330390,
umls-concept:C0332285,
umls-concept:C0337051,
umls-concept:C0524637,
umls-concept:C0599840,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1509144,
umls-concept:C1706438,
umls-concept:C2003941,
umls-concept:C2698600
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pubmed:issue |
1
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pubmed:dateCreated |
1999-1-21
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pubmed:abstractText |
It is generally accepted that TCR alphabeta+ CD8+ T cells recognize immunogenic peptides bound to MHC-encoded class I molecules. This recognition is a major component of the cellular response mediating immune protection and recovery from viral infections and from certain intracellular bacterial infections. Here, we report two human CD8+ TCR alphabeta+ T cell lines specific for Mycobacterium tuberculosis Ags presented in the context of CD1a or CD1c Ag-presenting molecules. These T cells recognize lipid Ags and display cytotoxicity as well as strong Th cell type I cytokine responses. By extending presentation by the CD1 system to the major TCR alphabeta+ CD8+ T cell pool, this system gains wider applicability beyond the double negative subset of T cells previously shown to have this reactivity. This implies that previous assumptions about the role of CD8+ T cells in microbial immunity may require revision as the relative proportions of CD1-restricted and MHC class I-restricted CD8+ T cells are further defined.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Blocking,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Glycolipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
366-71
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9886408-Antibodies, Blocking,
pubmed-meshheading:9886408-Antibodies, Monoclonal,
pubmed-meshheading:9886408-Antigens, Bacterial,
pubmed-meshheading:9886408-Antigens, CD1,
pubmed-meshheading:9886408-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9886408-Cell Line,
pubmed-meshheading:9886408-Chromatography, Gel,
pubmed-meshheading:9886408-Cytokines,
pubmed-meshheading:9886408-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:9886408-Epitopes, T-Lymphocyte,
pubmed-meshheading:9886408-Glycolipids,
pubmed-meshheading:9886408-Humans,
pubmed-meshheading:9886408-Lipids,
pubmed-meshheading:9886408-Lymphocyte Activation,
pubmed-meshheading:9886408-Mycobacterium tuberculosis,
pubmed-meshheading:9886408-Phospholipids,
pubmed-meshheading:9886408-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9886408-T-Lymphocyte Subsets
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pubmed:year |
1999
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pubmed:articleTitle |
CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool.
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pubmed:affiliation |
Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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