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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-1-21
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pubmed:databankReference |
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pubmed:abstractText |
Genetic relationships among viruses defining the Venezuelan equine encephalitis (VEE) virus antigenic complex were determined by analyzing the 3'-terminal 561 nucleotides of the nonstructural protein 4 gene and the entire 26S RNA region of the genome. New sequence information is reported for VEE 78V-3531 (VEE subtype-variety IF), Mucambo (IIIA), Tonate (IIIB), 71D-1252 (IIIC), Pixuna (IV), Cabassou (V), and AG80-663 (VI) viruses. The results reported here and by previous investigators largely support the current classification scheme of these viruses, while clearly identifying Everglades (II) as a subtype I virus. A genetic relationship between 78V-3531 (IF) and AG80-663 (VI) viruses contradicted previous serologic results. Mutations near the amino terminus of the E2 envelope proteins of Pixuna and AG80-663 viruses probably account for the previously reported low reactivity of the protective monoclonal antibody 1A2B-10 with these two viruses. Variations in the distribution of potential glycosylation sites in the E2 glycoprotein are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9637
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
952-64
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:9886206-Amino Acid Sequence,
pubmed-meshheading:9886206-Antigens, Viral,
pubmed-meshheading:9886206-Base Sequence,
pubmed-meshheading:9886206-Capsid,
pubmed-meshheading:9886206-DNA, Complementary,
pubmed-meshheading:9886206-Encephalitis Virus, Venezuelan Equine,
pubmed-meshheading:9886206-Molecular Sequence Data,
pubmed-meshheading:9886206-RNA, Messenger,
pubmed-meshheading:9886206-RNA, Viral,
pubmed-meshheading:9886206-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:9886206-Viral Envelope Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Nucleotide sequences of the 26S mRNAs of the viruses defining the Venezuelan equine encephalitis antigenic complex.
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pubmed:affiliation |
Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA.
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pubmed:publicationType |
Journal Article
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