Linked Life Data

988596

Source:http://linkedlifedata.com/resource/pubmed/id/988596

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1977-1-3
pubmed:abstractText
1. The effects of lithium on electrolyte metabolism can be demonstrated in man in acute as well as in long-term lithium treatment. No other lithium effects have been reproducible to a similar extent. 2. It seems feasible to integrate these lithium effects with effects on biogenic amines to form an integral hypothesis for lithium action in manic-melancholic man. 3. The results are consistent with one of the following two hypotheses: a) that lithium acts by membrane stabilization and/or b) that lithium acts by interplay with magnesium on one or more enzymes. 4. The above findings and hypotheses direct our attention to membrane dysfunction as the basic defect in manic-melancholic states. This may find support in our preliminary findings of special HL-A profiles in unipolar and bipolar manic-melancholic patients. 5. A four-type-pump-defect model to account for the various clinical types of affective disorders is proposed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-7098
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
108-15
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Lithium in the living organism. Is an integrated hypothesis feasible?
pubmed:publicationType
Journal Article