Linked Life Data

9883875

Source:http://linkedlifedata.com/resource/pubmed/id/9883875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-1-22
pubmed:abstractText
Defects in the human mitochondrial genetic system result in some diseases. These disorders are the result of rearrangements or point mutations in mitochondrial genes. In higher plants mutations and rearrangements in the mitochondrial DNA are believed to cause cytoplasmic male sterility (CMS), a mitochondrially inherited inability to produce viable pollen. In sorghum, formation of CMS is strongly correlated with anther-specific loss of mitochondrial atp6 RNA editing. Here we show that this loss of atp6 RNA editing mimics point mutations at codons that cause severe disorders in humans. We conclude that (i) loss of RNA editing in sorghum anthers probably causes CMS, (ii) similarities exist in the onset of mitochondrial dysfunction in plant and human tissues, and (iii) the evolutionary appearance of RNA editing provided a mechanism to compensate for otherwise lethal point mutations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
441
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-60
pubmed:dateRevised
2006-11-20
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Mutations at specific atp6 codons which cause human mitochondrial diseases also lead to male sterility in a plant.
pubmed:affiliation
Lehrstuhl für Allgemeine Botanik, Ruhr-Universität Bochum, Germany. frank.kempken@ruhr-uni-bochum.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't