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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-1-26
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pubmed:abstractText |
Hippocampal long-term potentiation (LTP) and long-term depression (LTD) are the most widely studied forms of synaptic plasticity thought to underlie spatial learning and memory. We report here that RARbeta deficiency in mice virtually eliminates hippocampal CA1 LTP and LTD. It also results in substantial performance deficits in spatial learning and memory tasks. Surprisingly, RXRgamma null mice exhibit a distinct phenotype in which LTD is lost whereas LTP is normal. Thus, while retinoid receptors contribute to both LTP and LTD, they do so in different ways. These findings not only genetically uncouple LTP and LTD but also reveal a novel and unexpected role for vitamin A in higher cognitive functions.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1353-61
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9883728-Animals,
pubmed-meshheading:9883728-Excitatory Postsynaptic Potentials,
pubmed-meshheading:9883728-Hippocampus,
pubmed-meshheading:9883728-Long-Term Potentiation,
pubmed-meshheading:9883728-Maze Learning,
pubmed-meshheading:9883728-Mice,
pubmed-meshheading:9883728-Mice, Knockout,
pubmed-meshheading:9883728-Neuronal Plasticity,
pubmed-meshheading:9883728-Phenotype,
pubmed-meshheading:9883728-Receptors, Retinoic Acid,
pubmed-meshheading:9883728-Retinoid X Receptors,
pubmed-meshheading:9883728-Space Perception,
pubmed-meshheading:9883728-Synapses,
pubmed-meshheading:9883728-Synaptic Transmission,
pubmed-meshheading:9883728-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression.
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pubmed:affiliation |
Gene Expression Laboratory, The Salk Institute for Biological Studies, Howard Hughes Medical Institute, La Jolla, California 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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