Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1978-10-27
|
| pubmed:abstractText |
The side-effects of oral contraceptives on the nervous system have been studied in 2 patients. The first case, a young woman who, after several years, of cyclic consumption of 4 mg of norethylsterone acetate and 0.05 mg of ethynilestradiol, died from a transtentorial temporal hernia due to severe intracranial hypertension. Angiography, and later autopsy, showed thrombosis of the dural venous sinuses and also of the majority of the emissary veins with C.S.F. blockage. The second case, a patient who took 1 mg of norethyndrone and 0.05 mg of mestranol for 20 months, developed a focal symptomatology (Grand Mal, global aphasia without lowering of the level of conscionsness) which cleared up rapidly. The CAT performed during the clinical illness showed mild signs of intracranial hypertension while cerebral angiography normal. It seems possible that the hormonal treatment may disturb the mechanisms of C.S.F. production-reabsorbtion and the filtration dynamics of the blood-brain barrier and perhaps, cause alteration of hypothalamic-hypophysial function. This would explain a transitory symptomatology, such as benign intracranial hypertension. However, the thrombosis of the venous sinuses (sometimes, as in our first case, massive) may be due to the venous stasis, that accompanies intracranial hypertension and to the altered blood coagulation.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Blood Coagulation Effects,
http://linkedlifedata.com/resource/pubmed/keyword/CENTRAL NERVOUS SYSTEM,
http://linkedlifedata.com/resource/pubmed/keyword/Case Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Central Nervous System Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/EMBOLISM,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Hypertension,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/THROMBOEMBOLISM,
http://linkedlifedata.com/resource/pubmed/keyword/THROMBOSIS,
http://linkedlifedata.com/resource/pubmed/keyword/Vascular Diseases
|
| pubmed:language |
ita
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0035-6433
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
98
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
185-90
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:otherAbstract |
PIP: 2 cases of serious complications from oral contraception are presented. The first patient, on oral contraception for some time, died of a temporal hernia due to severe intracranial hypertension. Autopsy and angiography revealed thrombosis of the venous sinuses. The second patient, on oral contraception for 20 months, developed sudden aphasia and epilepsy without ever losing consciousness; tests showed intracranial hypertension, but a normal angiography. She recovered rapidly after treatment and after suspension of oral contraception. Oral contraceptives might alter the mechanism of production and reabsorption of cerebrospinal fluid, and also disturb the hypothalamo-hypophyseal function. The article includes a short review of studies on the problem.
|
| pubmed:meshHeading |
pubmed-meshheading:98825-Adult,
pubmed-meshheading:98825-Aphasia,
pubmed-meshheading:98825-Contraceptives, Oral,
pubmed-meshheading:98825-Epilepsy, Tonic-Clonic,
pubmed-meshheading:98825-Ethinyl Estradiol,
pubmed-meshheading:98825-Female,
pubmed-meshheading:98825-Humans,
pubmed-meshheading:98825-Mestranol,
pubmed-meshheading:98825-Norethindrone,
pubmed-meshheading:98825-Pseudotumor Cerebri,
pubmed-meshheading:98825-Sinus Thrombosis, Intracranial
|
| pubmed:articleTitle |
[Benign intracranial hypertension and thrombosis of the venous sinuses during contraceptive treatment: anatomo-clinical and neuroradiological observations (author's transl)].
|
| pubmed:publicationType |
Journal Article,
English Abstract,
Case Reports
|