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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-3-16
pubmed:abstractText
Bilateral olfactory bulbectomy in the rat produces a well-characterized syndrome that is independent of anosmia. This syndrome is reversed by chronic antidepressant administration, which provides the basis for the olfactory bulbectomy model of depression. The present experiments focused on neuropeptide plasticity in central olfactory/limbic structures following olfactory bulbectomy in rats. Male Sprague-Dawley rats received bilateral surgical ablation of the olfactory bulbs, sham surgery, or no surgery and were killed either three, seven, 14 or 28 days later. Relative levels of messenger RNA encoding neuropeptide Y, somatostatin, thyrotropin-releasing hormone, and corticotropin-releasing factor precursors in the forebrain were measured by quantitative in situ hybridization histochemistry using oligonucleotide probes. Prepro-neuropeptide Y messenger RNA levels in the piriform cortex and dentate gyrus were significantly elevated in bulbectomized rats 14 and 28 days after surgery compared to sham-operated and surgically naive rats. Prepro-somatostatin messenger RNA levels in the piriform cortex were marginally increased in bulbectomized rats at these time-points. Thyrotropin-releasing hormone and corticotropin-releasing factor precursor messenger RNA levels were not altered in the brain regions studied. The results indicate that olfactory bulbectomy causes long-term increases in the expression of the neuropeptide Y gene. These findings suggest that neuropeptide Y plasticity in the olfactory/limbic system may contribute to the olfactory bulbectomy syndrome in rats, and they provide further evidence of a role for neuropeptide Y in the pathophysiology of depression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
587-96
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9881871-Animals, pubmed-meshheading:9881871-Corticotropin-Releasing Hormone, pubmed-meshheading:9881871-Functional Laterality, pubmed-meshheading:9881871-Gene Expression Regulation, pubmed-meshheading:9881871-In Situ Hybridization, pubmed-meshheading:9881871-Limbic System, pubmed-meshheading:9881871-Male, pubmed-meshheading:9881871-Neuropeptide Y, pubmed-meshheading:9881871-Neuropeptides, pubmed-meshheading:9881871-Olfaction Disorders, pubmed-meshheading:9881871-Olfactory Bulb, pubmed-meshheading:9881871-Olfactory Pathways, pubmed-meshheading:9881871-Prosencephalon, pubmed-meshheading:9881871-Protein Precursors, pubmed-meshheading:9881871-RNA, Messenger, pubmed-meshheading:9881871-Rats, pubmed-meshheading:9881871-Rats, Sprague-Dawley, pubmed-meshheading:9881871-Reference Values, pubmed-meshheading:9881871-Somatostatin, pubmed-meshheading:9881871-Thyrotropin-Releasing Hormone, pubmed-meshheading:9881871-Time Factors, pubmed-meshheading:9881871-Transcription, Genetic
pubmed:year
1998
pubmed:articleTitle
Effects of olfactory bulbectomy on neuropeptide gene expression in the rat olfactory/limbic system.
pubmed:affiliation
Psychology Department, The University of Georgia, Athens 30602, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't