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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1999-3-17
|
| pubmed:abstractText |
Sturge-Weber syndrome is characterized by the presence of a port-wine nevus, epilepsy, stroke-like episodes, headache, and developmental delay. We studied 20 cases to test the hypothesis that decreased cerebral blood flow alters neurologic function by affecting cellular glucose metabolism. Group A consisted of 10 patients with a mean age of 1.75 years and early seizure onset (6.8 months), whereas group B was composed of older patients (mean age, 15.3 years) with later onset of seizures (3.7 years). Neurologic disease was more severe in group A, but group B had more widespread structural brain defects - shown on computed tomographic scans and magnetic resonance imaging - and metabolic brain defects shown on hexamethylpropyleneamine oxime and [18F] fluorodeoxyglucose single photon emission computed tomographic scans. Six group A cases had hypoperfusion at baseline and five of nine had worsening of perfusion and glucose metabolism 1 year later. A total of 119 stroke-like episodes occurred in six group A cases and eight group B cases; there were 65% fewer strokes in children treated with aspirin. The data suggest that progressive hypoperfusion and glucose hypometabolism are associated with neurologic deterioration in Sturge-Weber syndrome. Longitudinal studies are needed to better define the natural history of disease and to evaluate the safety and efficacy of aspirin therapy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0883-0738
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
606-18
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9881531-Adolescent,
pubmed-meshheading:9881531-Adult,
pubmed-meshheading:9881531-Age of Onset,
pubmed-meshheading:9881531-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:9881531-Aspirin,
pubmed-meshheading:9881531-Brain,
pubmed-meshheading:9881531-Cerebrovascular Disorders,
pubmed-meshheading:9881531-Child,
pubmed-meshheading:9881531-Child, Preschool,
pubmed-meshheading:9881531-Female,
pubmed-meshheading:9881531-Follow-Up Studies,
pubmed-meshheading:9881531-Glucose,
pubmed-meshheading:9881531-Humans,
pubmed-meshheading:9881531-Infant,
pubmed-meshheading:9881531-Magnetic Resonance Imaging,
pubmed-meshheading:9881531-Male,
pubmed-meshheading:9881531-Seizures,
pubmed-meshheading:9881531-Sturge-Weber Syndrome,
pubmed-meshheading:9881531-Tomography, X-Ray Computed
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Central nervous system structure and function in Sturge-Weber syndrome: evidence of neurologic and radiologic progression.
|
| pubmed:affiliation |
Department of Pediatrics, University of Florida College of Medicine, Gainesville, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|