| pubmed-article:9881508 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9881508 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9881508 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9881508 | lifeskim:mentions | umls-concept:C0079488 | lld:lifeskim |
| pubmed-article:9881508 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:9881508 | lifeskim:mentions | umls-concept:C1704242 | lld:lifeskim |
| pubmed-article:9881508 | lifeskim:mentions | umls-concept:C1819461 | lld:lifeskim |
| pubmed-article:9881508 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9881508 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:9881508 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9881508 | pubmed:dateCreated | 1999-1-22 | lld:pubmed |
| pubmed-article:9881508 | pubmed:abstractText | Interleukin-8 (IL-8) production by the gastric mucosa is increased in Helicobacter pylori infection. Previous studies indicated that H. pylori induces IL-8 synthesis in cancer cell lines, and the ability of H. pylori to stimulate IL-8 production is supposed to be associated with cagA and other cag pathogenicity island genes, including picB gene. In the present study, we investigated the induction of IL-8 in primary cultures of normal human gastric epithelial cells to elucidate the IL-8 induction by wild type strains and by the picB knockout strain. Human gastric epithelial cells were obtained from surgically resected specimens from four patients. Three H. pylori strains (TN2F4; type 1 clinical isolate, TN2F4m1; isogenic picB mutant of TN2F4, Tx30a; type 2 strain) were cocultured with the normal gastric epithelial cells or the transformed MKN-28. IL-8 levels in culture medium were determined by enzyme immunoassay. Human gastric epithelial cells produced IL-8 at a 10-50 times higher level than MKN-28 did when cocultured with TN2F4. The mutant TN2F4m1 induced IL-8 at significantly lower levels than the parent strain. Cells from four patients behaved similarly on IL-8 production. The results of the present study demonstrated the induction of IL-8 in normal gastric epithelial cells, suggesting that picB gene product may play an essential role in vivo. | lld:pubmed |
| pubmed-article:9881508 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9881508 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9881508 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9881508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9881508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9881508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9881508 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9881508 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9881508 | pubmed:issn | 0163-2116 | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:TakahashiMM | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:IkenoueTT | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:YoshidaHH | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:MoriKK | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:MaedaSS | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:OguraKK | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:OmataMM | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:ShiratoriYY | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:KanaiFF | lld:pubmed |
| pubmed-article:9881508 | pubmed:author | pubmed-author:MafuneK IKI | lld:pubmed |
| pubmed-article:9881508 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9881508 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:9881508 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9881508 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9881508 | pubmed:pagination | 2738-43 | lld:pubmed |
| pubmed-article:9881508 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:9881508 | pubmed:meshHeading | pubmed-meshheading:9881508-... | lld:pubmed |
| pubmed-article:9881508 | pubmed:meshHeading | pubmed-meshheading:9881508-... | lld:pubmed |
| pubmed-article:9881508 | pubmed:meshHeading | pubmed-meshheading:9881508-... | lld:pubmed |
| pubmed-article:9881508 | pubmed:meshHeading | pubmed-meshheading:9881508-... | lld:pubmed |
| pubmed-article:9881508 | pubmed:meshHeading | pubmed-meshheading:9881508-... | lld:pubmed |
| pubmed-article:9881508 | pubmed:meshHeading | pubmed-meshheading:9881508-... | lld:pubmed |
| pubmed-article:9881508 | pubmed:meshHeading | pubmed-meshheading:9881508-... | lld:pubmed |
| pubmed-article:9881508 | pubmed:meshHeading | pubmed-meshheading:9881508-... | lld:pubmed |
| pubmed-article:9881508 | pubmed:meshHeading | pubmed-meshheading:9881508-... | lld:pubmed |
| pubmed-article:9881508 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9881508 | pubmed:articleTitle | Interleukin-8 production in primary cultures of human gastric epithelial cells induced by Helicobacter pylori. | lld:pubmed |
| pubmed-article:9881508 | pubmed:affiliation | Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:9881508 | pubmed:publicationType | Journal Article | lld:pubmed |
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