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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-2-16
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pubmed:abstractText |
The suprachiasmatic nuclei (SCN) contain the principal circadian clock governing overt daily rhythms of physiology and behavior. The endogenous circadian cycle is entrained to the light/dark via direct glutamatergic retinal afferents to the SCN. To understand the molecular basis of entrainment, it is first necessary to define how rapidly the clock is reset by a light pulse. We used a two-pulse paradigm, in combination with cellular and behavioral analyses of SCN function, to explore the speed of resetting of the circadian oscillator in Syrian hamster and mouse. Analysis of c-fos induction and cAMP response element-binding protein phosphorylation in the retinorecipient SCN demonstrated that the SCN are able to resolve and respond to light pulses presented 1 or 2 hr apart. Analysis of the phase shifts of the circadian wheel-running activity rhythm of hamsters presented with single or double pulses demonstrated that resetting of the oscillator occurred within 2 hr. This was the case for both delaying and advancing phase shifts. Examination of delaying shifts in the mouse showed resetting within 2 hr and in addition showed that resetting is not completed within 1 hr of a light pulse. These results establish the temporal window within which to define the primary molecular mechanisms of circadian resetting in the mammal.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-6474
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
828-35
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:9880602-Animals,
pubmed-meshheading:9880602-Autoradiography,
pubmed-meshheading:9880602-Blotting, Western,
pubmed-meshheading:9880602-Circadian Rhythm,
pubmed-meshheading:9880602-Cricetinae,
pubmed-meshheading:9880602-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:9880602-In Situ Hybridization,
pubmed-meshheading:9880602-Light,
pubmed-meshheading:9880602-Male,
pubmed-meshheading:9880602-Mesocricetus,
pubmed-meshheading:9880602-Mice,
pubmed-meshheading:9880602-Mice, Inbred ICR,
pubmed-meshheading:9880602-Phosphorylation,
pubmed-meshheading:9880602-Photic Stimulation,
pubmed-meshheading:9880602-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:9880602-Suprachiasmatic Nucleus,
pubmed-meshheading:9880602-Transcription, Genetic
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pubmed:year |
1999
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pubmed:articleTitle |
Rapid resetting of the mammalian circadian clock.
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pubmed:affiliation |
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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