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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-2-19
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pubmed:abstractText |
Our study is to demonstrate the advantages and disadvantages of middle cerebral artery occlusion (MCAO) model in the mouse. CD-1 mice had permanent MCAO for 24 h, or temporary occlusion for either 1 h followed by 23 h of reperfusion or 2 h of occlusion with 22 h of reperfusion. The infarct volume and blood-brain barrier disruption were smaller in the 1-h/23-h temporary occlusion than in either the 24-h permanent occlusion group or the 2-h/22-h temporary occlusion group (p<0.05). Our study demonstrates that blood flow, infarct volume, and blood-brain barrier disruption remain important markers of focal cerebral ischemia.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0169-328X
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 1999 Elsevier Science B.V.
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
366-70
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9878831-Acute Disease,
pubmed-meshheading:9878831-Animals,
pubmed-meshheading:9878831-Arterial Occlusive Diseases,
pubmed-meshheading:9878831-Blood-Brain Barrier,
pubmed-meshheading:9878831-Cerebral Arteries,
pubmed-meshheading:9878831-Chronic Disease,
pubmed-meshheading:9878831-Disease Models, Animal,
pubmed-meshheading:9878831-Ischemic Attack, Transient,
pubmed-meshheading:9878831-Male,
pubmed-meshheading:9878831-Mice,
pubmed-meshheading:9878831-Mice, Inbred Strains,
pubmed-meshheading:9878831-Reperfusion
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pubmed:year |
1999
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pubmed:articleTitle |
Focal cerebral ischemia in the mouse: description of a model and effects of permanent and temporary occlusion.
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pubmed:affiliation |
Department of Neurosurgery, Institute of Neurology, Hua Shan Hospital, Shanghai Medical University, Shanghai 200040, China.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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